Patent classifications
C07C65/24
Catalytic glycosylation with designer thioglycoside and novel protecting groups for same and for synthesis of oligosaccharides
A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.
NOVEL AROMATIC COMPOUNDS
The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.
NOVEL AROMATIC COMPOUNDS
The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.
Synthetic processes and intermediates
The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.
Synthetic processes and intermediates
The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.
RESORCINOL-BASED COMPOUNDS AND USES THEREOF
The disclosure provides for resorcinol-based compounds, pharmaceutical compositions made therefrom, and methods of treatment thereof for various disorders, including neoplastic disorders.
CATALYTIC GLYCOSYLATION WITH DESIGNER THIOGLYCOSIDE AND NOVEL PROTECTING GROUPS FOR SAME AND FOR SYNTHESIS OF OLIGOSACCHARIDES
A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.
PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS
The invention relates to pyridone amide compounds of formula I and I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels:
##STR00001##
The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents
The present invention provides a compound of the formula:
##STR00001##
wherein R.sup.1 is a hydrogen or a COOH, R.sup.2 is a hydrogen or a COOH, R.sup.3 is a hydrogen or a COOH, R.sup.4 is one selected from the group consisting of H, COOH, and CH.sub.2COOH, and R.sup.5 is one selected from the group consisting of H, COOH, and CH.sub.2COOH. The present invention provides a compound having the formula:
##STR00002## wherein R is COOH or CH.sub.2COOH. Pharmaceutical compositions comprising one of these compounds and at least one of an acceptable pharmaceutical carrier, are provided. Methods of treating a patient having cancer are provided.
SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents
The present invention provides a compound of the formula:
##STR00001##
wherein R.sup.1 is a hydrogen or a COOH, R.sup.2 is a hydrogen or a COOH, R.sup.3 is a hydrogen or a COOH, R.sup.4 is one selected from the group consisting of H, COOH, and CH.sub.2COOH, and R.sup.5 is one selected from the group consisting of H, COOH, and CH.sub.2COOH. The present invention provides a compound having the formula:
##STR00002## wherein R is COOH or CH.sub.2COOH. Pharmaceutical compositions comprising one of these compounds and at least one of an acceptable pharmaceutical carrier, are provided. Methods of treating a patient having cancer are provided.