The disclosure provides a decolorization and purification method of BHET material, which includes the following steps. A first dose of activated carbon is added to preliminarily treat the BHET material. After the preliminary treatment, a first cooling crystallization process and filtration are performed to obtain BHET crystals. Afterwards, an oxidant is used to chemically react with the BHET crystals to destroy a dye or impurities, and then a second dose of activated carbon is added to adsorb a chemically reacted oxide. Next, a second cooling crystallization process, filtration, and drying are performed to obtain a finished product of BHET.

The disclosure provides a decolorization and purification method of BHET material, which includes the following steps. A first dose of activated carbon is added to preliminarily treat the BHET material. After the preliminary treatment, a first cooling crystallization process and filtration are performed to obtain BHET crystals. Afterwards, an oxidant is used to chemically react with the BHET crystals to destroy a dye or impurities, and then a second dose of activated carbon is added to adsorb a chemically reacted oxide. Next, a second cooling crystallization process, filtration, and drying are performed to obtain a finished product of BHET.

The present invention provides a process for producing a compound represented by formula (I), comprising the steps of (a) reacting a compound represented by formula (II) with dimethyl sulfate in the presence of an alkali carbonate in a aqueous ketone solvent to obtain the compound represented by formula (I) as a crystalline material, and (b) washing the crystalline material with heated water at 30 to 100° C. and then further washing with an organic solvent at 30 to 80° C.

The present invention provides a process for producing a compound represented by formula (I), comprising the steps of (a) reacting a compound represented by formula (II) with dimethyl sulfate in the presence of an alkali carbonate in a aqueous ketone solvent to obtain the compound represented by formula (I) as a crystalline material, and (b) washing the crystalline material with heated water at 30 to 100° C. and then further washing with an organic solvent at 30 to 80° C.

A process for synthesizing (R)-3 -hy droxybutyl (R)-3 -hy droxybutanoate from ethyl (R)-3-hydroxybutanoate and (R)-1,3-butanediol, as well a process for synthesizing (R)-3-hy droxybutyl (R)-3-hy droxybutanoate from (R)-3-hydroxybutyric acid and (R)-1,3-butanediol. Also provided are processes for isolating (R)-3-hy droxybutyl (R)-3-hy droxybutanoate, including from a fermentation broth.

A process for synthesizing (R)-3 -hy droxybutyl (R)-3 -hy droxybutanoate from ethyl (R)-3-hydroxybutanoate and (R)-1,3-butanediol, as well a process for synthesizing (R)-3-hy droxybutyl (R)-3-hy droxybutanoate from (R)-3-hydroxybutyric acid and (R)-1,3-butanediol. Also provided are processes for isolating (R)-3-hy droxybutyl (R)-3-hy droxybutanoate, including from a fermentation broth.

The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.

The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.

The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.

The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps.