The present invention relates to a method for preparing a fluorinated methacrylate compound which can be used as a fluorine monomer for synthesizing a functional polymer having high oxygen permeability, water repellency and stain resistance. Specifically, the method can be carried out by a process of reacting an alcohol derivative and methacrylic acid anhydride in the presence of an imidazole-based base to obtain a fluorinated methacrylate. According to the preparation method of the present invention, since the reaction is carried out at room temperature and there is no process of removing the byproducts formed during the reaction, a high yield of fluorinated methacrylate can be obtained by a simple method within a short period of time.

Isomerized olefin products are produced by contacting an olefin feed containing a C.sub.10 to C.sub.20 normal alpha olefin, a solid acid catalyst, and a C.sub.2 to C.sub.15 primary ester to form the isomerized olefin product. Typical primary esters used in the processes include formates and acetates. Linear olefin compositions are produced that contain at least 80 wt. % C.sub.10 to C.sub.20 linear internal olefins, less than 8 wt. % C.sub.10 to C.sub.20 normal alpha olefins, less than 8 wt. % dimers of C.sub.10 to C.sub.20 olefins, less than 15 wt. % C.sub.10 to C.sub.20 branched olefins, and at least 1 wt. % C.sub.2 to C.sub.15 primary ester and less than 8 wt. % secondary esters.

The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.

The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.

The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.

The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.

The present invention provides a compound represented by general formula (1). ##STR00001##
(In the formula, R.sup.1 represents an alkyl group having 2 to 9 carbon atoms, an alkenyl group having 2 to 9 carbon atoms, a cyclic alkyl group having 3 to 10 carbon atoms which may have a substituent, or a phenyl group which may have a substituent; R.sup.2 represents an alkyl group having 1 to 3 carbon atoms; R.sup.3 to R.sup.5 independently represent a hydrogen atom, or an alkyl group having 1 to 3 carbon atoms; R.sup.6 represents an alkyl group having 1 to 5 carbon atoms, an alkenyl group having 2 to 5 carbon atoms, a cyclic alkyl group having 3 to 10 carbon atoms which may have a substituent, or an alkoxy group having 1 to 5 carbon atoms; n represents 0 or 1; and the wavy line represents a cis form, a trans form or a mixture of a cis form and a trans form.)

The present invention provides a compound represented by general formula (1). ##STR00001##
(In the formula, R.sup.1 represents an alkyl group having 2 to 9 carbon atoms, an alkenyl group having 2 to 9 carbon atoms, a cyclic alkyl group having 3 to 10 carbon atoms which may have a substituent, or a phenyl group which may have a substituent; R.sup.2 represents an alkyl group having 1 to 3 carbon atoms; R.sup.3 to R.sup.5 independently represent a hydrogen atom, or an alkyl group having 1 to 3 carbon atoms; R.sup.6 represents an alkyl group having 1 to 5 carbon atoms, an alkenyl group having 2 to 5 carbon atoms, a cyclic alkyl group having 3 to 10 carbon atoms which may have a substituent, or an alkoxy group having 1 to 5 carbon atoms; n represents 0 or 1; and the wavy line represents a cis form, a trans form or a mixture of a cis form and a trans form.)

Disclosed herein is an ophthalmic formulation comprising a compound of formula (I): ##STR00001## wherein R.sup.1 is a linear or branched C.sub.9-C.sub.33 alkyl or a linear or branched C.sub.9-C.sub.33 alkenyl with 1 to 4 double bonds; R.sup.2 is a linear or branched C.sub.9-C.sub.19 alkyl or a linear or branched C.sub.9-C.sub.19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.

Disclosed herein is an ophthalmic formulation comprising a compound of formula (I): ##STR00001## wherein R.sup.1 is a linear or branched C.sub.9-C.sub.33 alkyl or a linear or branched C.sub.9-C.sub.33 alkenyl with 1 to 4 double bonds; R.sup.2 is a linear or branched C.sub.9-C.sub.19 alkyl or a linear or branched C.sub.9-C.sub.19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.