C07C69/42

SUBSTITUTED ESTERS CONTAINING POLYOLS AND SACCHARIDES FOR TREATING HEPATOTOXICITY AND FATTY LIVER DISEASES

Compounds are of the structure of Formula (II)

##STR00001##

wherein: each X is C(?O); R.sub.1 is a C.sub.1-C.sub.18 alkyl polyol; R.sub.2 is a saccharide group of formula (G).sub.p; G is a monosaccharide residue, where (i) at least one of the OH groups in (G).sub.p is substituted by a halogen atom, and (ii) the saccharide group of formula (G).sub.p is linked to O through a CH.sub.2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. The compounds are effective in treating hepatotoxicity and fatty liver diseases.

Substituted esters containing polyols and saccharides for treating hepatotoxicity and fatty liver diseases

Compounds are of the structure of Formula (II) ##STR00001##
wherein: each X is C(?O); R.sub.1 is a C.sub.1-C.sub.18 alkyl polyol; R.sub.2 is a saccharide group of formula (G).sub.p; G is a monosaccharide residue, where (i) at least one of the OH groups in (G).sub.p is substituted by a halogen atom, and (ii) the saccharide group of formula (G).sub.p is linked to O through a CH.sub.2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. The compounds are effective in treating hepatotoxicity and fatty liver diseases.

Substituted esters containing polyols and saccharides for treating hepatotoxicity and fatty liver diseases

Compounds are of the structure of Formula (II) ##STR00001##
wherein: each X is C(?O); R.sub.1 is a C.sub.1-C.sub.18 alkyl polyol; R.sub.2 is a saccharide group of formula (G).sub.p; G is a monosaccharide residue, where (i) at least one of the OH groups in (G).sub.p is substituted by a halogen atom, and (ii) the saccharide group of formula (G).sub.p is linked to O through a CH.sub.2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. The compounds are effective in treating hepatotoxicity and fatty liver diseases.

COMPOUNDS EFFECTIVE IN TREATING HEPATOTOXICITY AND FATTY LIVER DISEASES AND USES THEREOF

The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof.

HEAT TRANSFER FLUIDS BASED ON SYNTHETIC ESTERS

Heat transfer fluids were formulated with a neat solution of a synthetic ester base stock. A base stock prepared with a neat ester according to the invention has similar performance characteristics to commercially available heat transfer fluids.

HEAT TRANSFER FLUIDS BASED ON SYNTHETIC ESTERS

Heat transfer fluids were formulated with a neat solution of a synthetic ester base stock. A base stock prepared with a neat ester according to the invention has similar performance characteristics to commercially available heat transfer fluids.

Methods, reagents and cells for biosynthesizing glutarate methyl ester

This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene.

Methods, reagents and cells for biosynthesizing glutarate methyl ester

This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene.

Methods, reagents and cells for biosynthesizing compounds

This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp].

Methods, reagents and cells for biosynthesizing compounds

This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp].