Compounds are provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

Compounds are provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

The present invention relates to modulators of lipoxygenase and/or cyclooxygenase enzyme. The present invention also provides compositions comprising such modulators, and methods therewith for treating lipoxygenase receptor mediated diseases.

The present invention relates to modulators of lipoxygenase and/or cyclooxygenase enzyme. The present invention also provides compositions comprising such modulators, and methods therewith for treating lipoxygenase receptor mediated diseases.

A process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles disposed therein. An aqueous gel ink with variable color obtained according to process for preparing, comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group and silver nanoparticles. A writing instrument comprising an aqueous gel ink with variable color.

A process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles disposed therein. An aqueous gel ink with variable color obtained according to process for preparing, comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group and silver nanoparticles. A writing instrument comprising an aqueous gel ink with variable color.

A process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising ester(s) of retinol represented by formula (I), and (ii) adding a solution of gold salts (Au3+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with gold nanoparticles dispersed therein. An aqueous gel ink with fixed color obtained according to the process of the invention, comprising the ester of retinol represented by formula (I) and gold nanoparticles. A writing instrument comprising an aqueous gel ink with fixed color. ##STR00001##

A process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising ester(s) of retinol represented by formula (I), and (ii) adding a solution of gold salts (Au3+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with gold nanoparticles dispersed therein. An aqueous gel ink with fixed color obtained according to the process of the invention, comprising the ester of retinol represented by formula (I) and gold nanoparticles. A writing instrument comprising an aqueous gel ink with fixed color. ##STR00001##

The present invention concerns a process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising ester(s) of retinol represented by formula (I), and (ii) adding a solution of gold salts (Au3+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with gold nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with fixed color obtained according to the process of the invention, comprising said ester of retinol represented by formula (I) and gold nanoparticles. The invention finally concerns a writing instrument comprising an aqueous gel ink with fixed color according to the invention.

##STR00001##

The present invention concerns a process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein said hydroxyl group is preferably in meta or in para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with variable color obtained according to the process of the invention, comprising an N-Acyl-aminophenol, wherein said hydroxyl group is preferably in meta or in para position on the benzenic group and silver nanoparticles. The invention finally concerns a writing instrument comprising an aqueous gel ink with variable color according to the invention.