Dental material which contains at least one vinylcyclopropane of the general formulae I,

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in which A, B independently of each other are in each case OH or COOH; X, Y independently of each other are in each case O or NH; R.sup.1, R.sup.2 independently of each other are in each case H or an aliphatic linear or branched C.sub.1-C.sub.10 hydrocarbon radical which can be interrupted by O, S or an ester group; and n, m independently of each other are in each case 0, 1 or 2, wherein, if X=Y=O, R.sup.1H and R.sup.2H, n+m1. The vinylcyclopropanes are characterized by a low shrinkage and a high reactivity on radical polymerization and are suitable in particular for the preparation of dental materials.

Dental material which contains at least one vinylcyclopropane of the general formulae I,

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in which A, B independently of each other are in each case OH or COOH; X, Y independently of each other are in each case O or NH; R.sup.1, R.sup.2 independently of each other are in each case H or an aliphatic linear or branched C.sub.1-C.sub.10 hydrocarbon radical which can be interrupted by O, S or an ester group; and n, m independently of each other are in each case 0, 1 or 2, wherein, if X=Y=O, R.sup.1H and R.sup.2H, n+m1. The vinylcyclopropanes are characterized by a low shrinkage and a high reactivity on radical polymerization and are suitable in particular for the preparation of dental materials.

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is CN or COOR in which R is a C.sub.1-C.sub.4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R.sub.1O and R.sub.1S wherein R.sub.1 is C1-C4 straight or branched alkyl chain. ##STR00001##

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is CN or COOR in which R is a C.sub.1-C.sub.4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R.sub.1O and R.sub.1S wherein R.sub.1 is C1-C4 straight or branched alkyl chain. ##STR00001##

Provided are a vinylcyclopropane that exhibits volume expansion upon homopolymerization and that enables improved solvent solubility, a monomer composition that contains the vinylcyclopropane, a polymer of the vinylcyclopropane, a polymer composition that contains the polymer, and an article that is obtainable through curing of the monomer composition. The vinylcyclopropane is represented by general formula (I) shown below. ##STR00001##

Provided are a vinylcyclopropane that exhibits volume expansion upon homopolymerization and that enables improved solvent solubility, a monomer composition that contains the vinylcyclopropane, a polymer of the vinylcyclopropane, a polymer composition that contains the polymer, and an article that is obtainable through curing of the monomer composition. The vinylcyclopropane is represented by general formula (I) shown below. ##STR00001##

Provided are a vinylcyclopropane that exhibits volume expansion upon homopolymerization and that enables improved solvent solubility, a monomer composition that contains the vinylcyclopropane, a polymer of the vinylcyclopropane, a polymer composition that contains the polymer, and an article that is obtainable through curing of the monomer composition. The vinylcyclopropane is represented by general formula (I) shown below.

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