The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulfuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied to the process per time interval) is particularly advantageously developed. The invention particularly relates to a method in which, in the case of a load reduction, the ratio of the masses of benzene and nitric acid supplied per time interval is significantly increased compared to said ratio before the load change and/or the ratio of the masses of nitric acid and sulfuric acid supplied per time interval is significantly reduced compared to said ratio before the load change. In the event of a load increase, the reverse is carried out.

The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulfuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied to the process per time interval) is particularly advantageously developed. The invention particularly relates to a method in which, in the case of a load reduction, the ratio of the masses of benzene and nitric acid supplied per time interval is significantly increased compared to said ratio before the load change and/or the ratio of the masses of nitric acid and sulfuric acid supplied per time interval is significantly reduced compared to said ratio before the load change. In the event of a load increase, the reverse is carried out.

The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulfuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied to the process per time interval) is particularly advantageously developed. The invention particularly relates to a method in which, in the case of a load reduction, the ratio of the masses of benzene and nitric acid supplied per time interval is significantly increased compared to said ratio before the load change and/or the ratio of the masses of nitric acid and sulfuric acid supplied per time interval is significantly reduced compared to said ratio before the load change. In the event of a load increase, the reverse is carried out.

The present invention relates to zeolite adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium, sodium and strontium. These adsorbents have applications in the separation of fractions of aromatic C8 isomers and in particular xylenes.

The present invention relates to zeolite adsorbents based on agglomerated zeolite X crystals comprising barium, potassium and sodium. These adsorbents find applications in the separation of aromatic C8 isomer fractions and especially xylene.