The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which nitrated crude nitric acid esters arise during the nitration of monovalent or multivalent aliphatic or alicyclic alcohols capable of nitration, after the separation of the final nitrating acid, and to a production system for nitrating monovalent or multivalent aliphatic alcohols capable of nitration with subsequent purification of the nitrated nitric acid esters.

Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.

Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.

The current invention relates to a purified bacterial strain for conferring a broad-spectrum pathogen control or resistance to a plant, wherein said strain comprises at least one 16S nucleotide sequence, said 16S nucleotide sequence shows at least 95% sequence identity to SEQ ID No 2 over the entire length of said sequence and comprises a nucleotide signature sequence according to SEQ ID No 1. The invention also relates to a bacterial population and to a formulation for conferring a broad-spectrum pathogen control or resistance to a plant, as well as to the use of such purified bacterial strain, bacterial population or formulation to control a pathogen in a plant. In addition, the invention relates to a compound having the formula C21H23NO4. The invention also relates to a method for conferring a broad-spectrum pathogen control or resistance in a plant, and to the use of Takanawaene and/or C21H23NO4 compounds for controlling a pathogen in a plant.

The current invention relates to a purified bacterial strain for conferring a broad-spectrum pathogen control or resistance to a plant, wherein said strain comprises at least one 16S nucleotide sequence, said 16S nucleotide sequence shows at least 95% sequence identity to SEQ ID No 2 over the entire length of said sequence and comprises a nucleotide signature sequence according to SEQ ID No 1. The invention also relates to a bacterial population and to a formulation for conferring a broad-spectrum pathogen control or resistance to a plant, as well as to the use of such purified bacterial strain, bacterial population or formulation to control a pathogen in a plant. In addition, the invention relates to a compound having the formula C21H23NO4. The invention also relates to a method for conferring a broad-spectrum pathogen control or resistance in a plant, and to the use of Takanawaene and/or C21H23NO4 compounds for controlling a pathogen in a plant.

A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4-HNO3 mixture and produce a reaction mixture stream flowing in said reactor, maintaining the reaction mixture stream flowing in said flow reactor at a reaction temperature within in the range 10 to 35 C. inclusive, and wherein the residence time of the reaction mixture stream in the flow reactor is greater than or equal to 5 seconds and less than or equal to 40 seconds, and wherein the H2SO4 of the H2SO4-HNO3 mixture is H2SO4 having a concentration of in the range of 85 to 95% inclusive, more desirably 88 to 92% inclusive, most desirably of 90%.

A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4-HNO3 mixture and produce a reaction mixture stream flowing in said reactor, maintaining the reaction mixture stream flowing in said flow reactor at a reaction temperature within in the range 10 to 35 C. inclusive, and wherein the residence time of the reaction mixture stream in the flow reactor is greater than or equal to 5 seconds and less than or equal to 40 seconds, and wherein the H2SO4 of the H2SO4-HNO3 mixture is H2SO4 having a concentration of in the range of 85 to 95% inclusive, more desirably 88 to 92% inclusive, most desirably of 90%.

The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these prodrugs.

The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these prodrugs.

Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.