The invention relates to a production process for polyamines through condensation of aromatic amines with formaldehyde employing at least one solid zeolite catalyst partially or fully ion-exchanged to the protonic form which has been A) alkaline-treated, wherein the alkaline treatment is in case of BEA zeolites carried out in the presence of a pore-directing agent and in case of zeolites other than BEA zeolites in the presence or absence of a pore-directing agent,
or B) acid-treated without any alkaline treatment preceding or following said acid treatment, wherein the acid treatment is effected with an organic acid with chelating function.

The invention relates to a production process for polyamines through condensation of aromatic amines with formaldehyde employing at least one solid zeolite catalyst partially or fully ion-exchanged to the protonic form which has been A) alkaline-treated, wherein the alkaline treatment is in case of BEA zeolites carried out in the presence of a pore-directing agent and in case of zeolites other than BEA zeolites in the presence or absence of a pore-directing agent,
or B) acid-treated without any alkaline treatment preceding or following said acid treatment, wherein the acid treatment is effected with an organic acid with chelating function.

The invention relates to a production process for polyamines through condensation of aromatic amines with formaldehyde employing at least one solid zeolite catalyst partially or fully ion-exchanged to the protonic form which has been A) alkaline-treated, wherein the alkaline treatment is in case of BEA zeolites carried out in the presence of a pore-directing agent and in case of zeolites other than BEA zeolites in the presence or absence of a pore-directing agent,
or B) acid-treated without any alkaline treatment preceding or following said acid treatment, wherein the acid treatment is effected with an organic acid with chelating function.

The present application provides for a compound of Formula I,

##STR00001##

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

The present invention relates to compounds TAAR receptor antagonists of formula I wherein X, R, L, Ar and R.sup.1 are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I.

##STR00001##

The present invention relates to compounds TAAR receptor antagonists of formula I wherein X, R, L, Ar and R.sup.1 are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I.

##STR00001##

The present invention relates to a process for preparing di- and polyamines of the diphenylmethane series (MDA), a system for producing MDA and a process for operating a system for preparing MDA. The invention enables optimization of production standstills during operation of the MDA process with respect to time expenditure and optionally also with respect to energy and material consumption by means of a so-called recirculation mode for individual system components. During interruption of the process or interruption of the operation of individual system components, formaldehyde is not introduced into the reaction and the system components that are not affected by a revision, repair, or cleaning measure are operated in so-called recirculation mode. This enables, among other things, that only the affected system component can be put in standstill during the time period of the measure, which is advantageous in terms of productivity and economy of the process as well as in terms of the quality of the products produced.

The present invention relates to a process for preparing di- and polyamines of the diphenylmethane series (MDA), a system for producing MDA and a process for operating a system for preparing MDA. The invention enables optimization of production standstills during operation of the MDA process with respect to time expenditure and optionally also with respect to energy and material consumption by means of a so-called recirculation mode for individual system components. During interruption of the process or interruption of the operation of individual system components, formaldehyde is not introduced into the reaction and the system components that are not affected by a revision, repair, or cleaning measure are operated in so-called recirculation mode. This enables, among other things, that only the affected system component can be put in standstill during the time period of the measure, which is advantageous in terms of productivity and economy of the process as well as in terms of the quality of the products produced.

The present invention relates to a process for preparing di- and polyamines of the diphenylmethane series (MDA), a system for producing MDA and a process for operating a system for preparing MDA. The invention enables optimization of production standstills during operation of the MDA process with respect to time expenditure and optionally also with respect to energy and material consumption by means of a so-called recirculation mode for individual system components. During interruption of the process or interruption of the operation of individual system components, formaldehyde is not introduced into the reaction and the system components that are not affected by a revision, repair, or cleaning measure are operated in so-called recirculation mode. This enables, among other things, that only the affected system component can be put in standstill during the time period of the measure, which is advantageous in terms of productivity and economy of the process as well as in terms of the quality of the products produced.

Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, in the presence of hydrogen, a nitrogen-containing compound, and a catalyst, wherein the presence of the nitrogen-containing compound, expressed in a molar ratio relative to the first functional group in the organic feed substrate, at least during the reaction as long as the conversion of the organic feed substrate has not yet reached 80%, is maintained below a level of 1.3. Further disclosed is a composition of the invention comprising at least 98.0% wt of 2-chloro-benzyl-dimethylamine, at most 0.60% wt of the meso-o-Cl-BDMA dimer and at least 1 ppm wt of the (+/)-o-Cl-BDMA dimer and any use therefor.