This is invention is related to processes for synthesis of levoamphetamine derivatives and novel intermediates thereby, and processes for using the same.

A process to convert cyclic alkylene ureas into their corresponding alkylene amines is provided. An exemplary process includes reacting the cyclic alkylene ureas with an amine compound chosen from the group of primary amines or secondary amines that have a higher boiling point than the alkylene amines formed during the process, wherein the process is a reactive separation process and the reaction mixture contains less than about 10 wt % of water on the basis of total weight of the reaction mixture.

A process to convert cyclic alkylene ureas into their corresponding alkylene amines is provided. An exemplary process includes reacting the cyclic alkylene ureas with an amine compound chosen from the group of primary amines or secondary amines that have a higher boiling point than the alkylene amines formed during the process, wherein the process is a reactive separation process and the reaction mixture contains less than about 10 wt % of water on the basis of total weight of the reaction mixture.

A process to convert cyclic alkylene ureas into their corresponding alkylene amines is provided. An exemplary process includes reacting the cyclic alkylene ureas with an amine compound chosen from the group of primary amines or secondary amines that have a higher boiling point than the alkylene amines formed during the process, wherein the process is a reactive separation process and the reaction mixture contains less than about 10 wt % of water on the basis of total weight of the reaction mixture.

The present invention relates to a process for purifying a mixture comprising MEG, MEA, EDA and DETA, and low boilers having a boiling point not higher than PIP and high boilers having a boiling point not lower than AEEA, wherein the process comprises the following steps: a) separating a mixture comprising MEG, MEA, EDA and DETA, and low boilers having a boiling point not higher than PIP and high boilers having a boiling point not lower than AEEA, into (i) a mixture A comprising EDA and the low boilers having a boiling point not higher than PIP; and (ii) a mixture B comprising MEA; and (iii) a mixture C comprising MEG, DETA and the high boilers having a boiling point not lower than AEEA; b) separating mixture C from stage a) into (i) a mixture D comprising MEG; and (ii) a mixture E comprising MEG, DETA and the high boilers having a boiling point not lower than AEEA; c) separating mixture E from stage b) either into (i) a mixture F comprising MEG and DETA; and (ii) a mixture G comprising the high boilers having a boiling point not lower than AEEA; or into (i) a mixture F comprising MEG and DETA; and (ii) a mixture G1 comprising AEEA; and (iii) a mixture G2 comprising the high boilers having a boiling point higher than AEEA; d) separating mixture F from stage c) by extractive distillation with triethylene glycol into (i) a mixture H comprising MEG; and (ii) a mixture I comprising DETA and TEG.

The present invention relates to a process for purifying a mixture comprising MEG, MEA, EDA and DETA, and low boilers having a boiling point not higher than PIP and high boilers having a boiling point not lower than AEEA, wherein the process comprises the following steps: a) separating a mixture comprising MEG, MEA, EDA and DETA, and low boilers having a boiling point not higher than PIP and high boilers having a boiling point not lower than AEEA, into (i) a mixture A comprising EDA and the low boilers having a boiling point not higher than PIP; and (ii) a mixture B comprising MEA; and (iii) a mixture C comprising MEG, DETA and the high boilers having a boiling point not lower than AEEA; b) separating mixture C from stage a) into (i) a mixture D comprising MEG; and (ii) a mixture E comprising MEG, DETA and the high boilers having a boiling point not lower than AEEA; c) separating mixture E from stage b) either into (i) a mixture F comprising MEG and DETA; and (ii) a mixture G comprising the high boilers having a boiling point not lower than AEEA; or into (i) a mixture F comprising MEG and DETA; and (ii) a mixture G1 comprising AEEA; and (iii) a mixture G2 comprising the high boilers having a boiling point higher than AEEA; d) separating mixture F from stage c) by extractive distillation with triethylene glycol into (i) a mixture H comprising MEG; and (ii) a mixture I comprising DETA and TEG.

A method for producing xylylenediamine, including performing a first hydrogenation including hydrogenating a mixed solution including dicyanobenzene and a solvent including liquid ammonia in a fixed-bed reactor such that a reaction product (A) is produced, performing ammonia separation including separating and removing liquid ammonia included in the reaction product (A) or a reaction product (D) such that a reaction product (B) or (E) is produced, performing solid-liquid separation including subjecting the reaction product (B) or (A) to solid-liquid separation and removing a solid component such that a reaction product (C) or the reaction product (D) is produced, and performing a second hydrogenation including hydrogenating the reaction product (C) or (E) in a fixed-bed reactor. After the first hydrogenation is performed, the ammonia separation and the solid-liquid separation are performed in this order or reverse order, followed by the second hydrogenation.

A method for producing xylylenediamine, including performing a first hydrogenation including hydrogenating a mixed solution including dicyanobenzene and a solvent including liquid ammonia in a fixed-bed reactor such that a reaction product (A) is produced, performing ammonia separation including separating and removing liquid ammonia included in the reaction product (A) or a reaction product (D) such that a reaction product (B) or (E) is produced, performing solid-liquid separation including subjecting the reaction product (B) or (A) to solid-liquid separation and removing a solid component such that a reaction product (C) or the reaction product (D) is produced, and performing a second hydrogenation including hydrogenating the reaction product (C) or (E) in a fixed-bed reactor. After the first hydrogenation is performed, the ammonia separation and the solid-liquid separation are performed in this order or reverse order, followed by the second hydrogenation.

The present invention relates to the crystalline form of phentermine hydrochloride monohydrate and processes for obtaining said crystalline form. Phentermine or 2-methyl-1-phenylpropan-2-amine is found in the hydrochloride salt form, being a central nervous system stimulant, used as an appetite suppressant and stimulant in medicaments. The present invention belongs to the fields of chemistry and pharmacy.

The present invention relates to the crystalline form of phentermine hydrochloride monohydrate and processes for obtaining said crystalline form. Phentermine or 2-methyl-1-phenylpropan-2-amine is found in the hydrochloride salt form, being a central nervous system stimulant, used as an appetite suppressant and stimulant in medicaments. The present invention belongs to the fields of chemistry and pharmacy.