The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.

The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.

The present application relates to mass spectrometry methods for use in identifying proteins or other biomolecules which are bound irreversibly by test compounds.

The present application relates to mass spectrometry methods for use in identifying proteins or other biomolecules which are bound irreversibly by test compounds.

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se. ##STR00001##

Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Fatty acids play very important and diverse roles in living organisms, from signal transduction, energy management, maintaining of structural integrity to the normal metabolic processes. Due to its diverse presence and roles, Fatty Acid Synthase (FAS) is an attractive drug target under different pathologic contexts such as cancer, TB, obesity, microbial infection, etc. There are a number of molecules targeting Fatty Acid Synthase (FAS) in the prior art like Cerulenin, Orlistat, Pyrimidine, Triclosan, C75 etc. The present invention relates to a compound of formula I having fatty acid synthase inhibitory properties which was confirmed by an FAS inhibition assay. The present invention also relates to a process for collection, extraction, isolation, purification and characterization of the claimed compound from marine cyanobacterium, Phormidium ambiguum. ##STR00001##

Fatty acids play very important and diverse roles in living organisms, from signal transduction, energy management, maintaining of structural integrity to the normal metabolic processes. Due to its diverse presence and roles, Fatty Acid Synthase (FAS) is an attractive drug target under different pathologic contexts such as cancer, TB, obesity, microbial infection, etc. There are a number of molecules targeting Fatty Acid Synthase (FAS) in the prior art like Cerulenin, Orlistat, Pyrimidine, Triclosan, C75 etc. The present invention relates to a compound of formula I having fatty acid synthase inhibitory properties which was confirmed by an FAS inhibition assay. The present invention also relates to a process for collection, extraction, isolation, purification and characterization of the claimed compound from marine cyanobacterium, Phormidium ambiguum. ##STR00001##

The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.