A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

The present application relates to mass spectrometry methods for use in identifying proteins or other biomolecules which are bound irreversibly by test compounds.

The present application relates to mass spectrometry methods for use in identifying proteins or other biomolecules which are bound irreversibly by test compounds.

Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is high in reaction yield in each step, low in waste gas and waste water and low in cost, and requires no special reaction equipment. ##STR00001##

Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is high in reaction yield in each step, low in waste gas and waste water and low in cost, and requires no special reaction equipment. ##STR00001##

The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPAR modulation such as diabetes.

The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPAR modulation such as diabetes.

The invention relates to a production method of pyrazole derivative (6) by reacting compound (5) with an oxidant. ##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, X.sup.1, X.sup.2 and Z.sup.1 are as defined herein.

The invention relates to a production method of pyrazole derivative (6) by reacting compound (5) with an oxidant. ##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, X.sup.1, X.sup.2 and Z.sup.1 are as defined herein.

The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.