The present invention relates to a process for preparing 3-(2-hydroxybenzoyloxy)-4-(trimethylammonio)butyrobetaine hydrochloride of formula (I), ##STR00001##
wherein the process comprises reacting 3-hydroxy-4-(trimethylammonio)butyrobetaine or a salt thereof with a 2-alkoxybenzoyl chloride of formula (III), ##STR00002##
and where R is selected from benzyl and branched C3-C6 alkyl groups. The present invention further relates to compounds of formula (II) and salts thereof, where R is selected from benzyl and branched C3-C6 alkyl groups, and to a process for preparing same. ##STR00003##

The invention relates to -amaninamide (1; x=0, 1 or 2), -amaninamidic acid (2; x=0, 1 or 2), and -amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of -amanitin (4), and methods and novel building blocks for the synthesis thereof. ##STR00001## ##STR00002##

The invention relates to -amaninamide (1; x=0, 1 or 2), -amaninamidic acid (2; x=0, 1 or 2), and -amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of -amanitin (4), and methods and novel building blocks for the synthesis thereof. ##STR00001## ##STR00002##

The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process and mixtures of chelating agents. In addition, the invention relates to methods where such mixtures are used.

The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process and mixtures of chelating agents. In addition, the invention relates to methods where such mixtures are used.

The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process and mixtures of chelating agents. In addition, the invention relates to methods where such mixtures are used.

Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.