The present invention relates to the preparation of -substituted -amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a -substituted -nitro dicarboxylic acid ester or of a -substituted -nitro dicarboxylate of general formula to a -substituted -nitro carboxylic acid and a subsequent reduction of the -nitro group to an amine group. In particular, the present invention relates to the preparation of (S)-pregabalin. In addition, the formation of enantiomerically enriched -substituted -amino carboxylic acids and -substituted -nitronate carboxylic acid salts are also described.

The present invention relates to the preparation of -substituted -amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a -substituted -nitro dicarboxylic acid ester or of a -substituted -nitro dicarboxylate of general formula to a -substituted -nitro carboxylic acid and a subsequent reduction of the -nitro group to an amine group. In particular, the present invention relates to the preparation of (S)-pregabalin. In addition, the formation of enantiomerically enriched -substituted -amino carboxylic acids and -substituted -nitronate carboxylic acid salts are also described.

The present invention relates to the preparation of -substituted -amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a -substituted -nitro dicarboxylic acid ester or of a -substituted -nitro dicarboxylate of general formula to a -substituted -nitro carboxylic acid and a subsequent reduction of the -nitro group to an amine group. In particular, the present invention relates to the preparation of (S)-pregabalin. In addition, the formation of enantiomerically enriched -substituted -amino carboxylic acids and -substituted -nitronate carboxylic acid salts are also described.

Disclosed is a compound represented by chemical formula (1): ##STR00001##
or chemical formula (2): ##STR00002##

Disclosed is a compound represented by chemical formula (1): ##STR00001##
or chemical formula (2): ##STR00002##

Disclosed is a compound represented by chemical formula (1): ##STR00001##
or chemical formula (2): ##STR00002##

The present invention relates to the preparation of -substituted -amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a -substituted -nitro dicarboxylic acid ester or of a -substituted -nitro dicarboxylate of general formula to a -substituted -nitro carboxylic acid and a subsequent reduction of the -nitro group to an amine group. In particular, the present invention relates to the preparation of (S)-pregabalin. In addition, the formation of enantiomerically enriched -substituted -amino carboxylic acids and -substituted -nitronate carboxylic acid salts are also described.

The present invention relates to the preparation of -substituted -amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a -substituted -nitro dicarboxylic acid ester or of a -substituted -nitro dicarboxylate of general formula to a -substituted -nitro carboxylic acid and a subsequent reduction of the -nitro group to an amine group. In particular, the present invention relates to the preparation of (S)-pregabalin. In addition, the formation of enantiomerically enriched -substituted -amino carboxylic acids and -substituted -nitronate carboxylic acid salts are also described.

The present invention relates to the preparation of -substituted -amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a -substituted -nitro dicarboxylic acid ester or of a -substituted -nitro dicarboxylate of general formula to a -substituted -nitro carboxylic acid and a subsequent reduction of the -nitro group to an amine group. In particular, the present invention relates to the preparation of (S)-pregabalin. In addition, the formation of enantiomerically enriched -substituted -amino carboxylic acids and -substituted -nitronate carboxylic acid salts are also described.

The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.