The present invention relates to a crumbly phase composition containing on total weight of the composition (i) 70-87 wt % of organic compounds and salts thereof containing 85 to 100 wt % on total organic compounds and salts thereof of MGDA-Na3, wherein at least 60 wt % of the MGDA-Na3 is crystalline, and (ii) 13-30 wt % of water

The invention furthermore relates to a process to prepare the above composition and a process to prepare crystals of MGDA-Na3 by drying the above composition.

The present invention relates to a crumbly phase composition containing on total weight of the composition (i) 70-87 wt % of organic compounds and salts thereof containing 85 to 100 wt % on total organic compounds and salts thereof of MGDA-Na3, wherein at least 60 wt % of the MGDA-Na3 is crystalline, and (ii) 13-30 wt % of water

The invention furthermore relates to a process to prepare the above composition and a process to prepare crystals of MGDA-Na3 by drying the above composition.

The present invention concerns a novel process for preparing solriamfetol hydrochloride.

The present invention concerns a novel process for preparing solriamfetol hydrochloride.

A process for the manufacture of ω-aminoalkanoic acid of formula NH.sub.2—(CH.sub.2).sub.n—COOH, in which n is an integer from 9 to 11, by reaction of the corresponding ω-bromoalkanoic acid with ammonia, including the following stages: i) reaction of the ω-bromoalkanoic acid with an aqueous excess ammonia solution, and ii) separation of the ω-aminoalkanoic acid formed from the reaction mixture. The aqueous ammonia solution exhibits a concentration of 35% to 70% by weight, and stage i) is carried out under a pressure greater than atmospheric pressure, from 0.11 to 2.0 MPa absolute.

A process for the manufacture of ω-aminoalkanoic acid of formula NH.sub.2—(CH.sub.2).sub.n—COOH, in which n is an integer from 9 to 11, by reaction of the corresponding ω-bromoalkanoic acid with ammonia, including the following stages: i) reaction of the ω-bromoalkanoic acid with an aqueous excess ammonia solution, and ii) separation of the ω-aminoalkanoic acid formed from the reaction mixture. The aqueous ammonia solution exhibits a concentration of 35% to 70% by weight, and stage i) is carried out under a pressure greater than atmospheric pressure, from 0.11 to 2.0 MPa absolute.

The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.

The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.