The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.

Described herein are novel - and -propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.

A blue light blocking film layer and a blue light blocking system are disclosed. The system comprises at least one blue light blocking film layer, and a basal layer, and one or more optional release film layers, wherein, the blue light blocking film layer is essential and includes at least a compound selected from formula (I-1), (II-1) and (II-2), ##STR00001##

A blue light blocking film layer and a blue light blocking system are disclosed. The system comprises at least one blue light blocking film layer, and a basal layer, and one or more optional release film layers, wherein, the blue light blocking film layer is essential and includes at least a compound selected from formula (I-1), (II-1) and (II-2), ##STR00001##

A blue light blocking compound and a use thereof, a blue light blocking composition and a use thereof, and a method for preparing a blue light blocking compound are provided. The blue light blocking compound is represented by the following formula 1. In the formula 1, R.sub.1 and R.sub.8 are each independently H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, halogen, N(R.sup.1a).sub.2, OR.sup.1b, SR.sup.1c, SO.sub.2R.sup.1d, COR.sup.1e, NO.sub.2, CN, SOR.sup.1h, a five-membered heterocycle, a six-membered heterocycle, or a fused ring structure formed by connecting R.sub.1 and R.sub.8.

##STR00001##

A blue light blocking compound and a use thereof, a blue light blocking composition and a use thereof, and a method for preparing a blue light blocking compound are provided. The blue light blocking compound is represented by the following formula 1. In the formula 1, R.sub.1 and R.sub.8 are each independently H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, halogen, N(R.sup.1a).sub.2, OR.sup.1b, SR.sup.1c, SO.sub.2R.sup.1d, COR.sup.1e, NO.sub.2, CN, SOR.sup.1h, a five-membered heterocycle, a six-membered heterocycle, or a fused ring structure formed by connecting R.sub.1 and R.sub.8.

##STR00001##