Patent classifications
C07C229/48
(S)-3-AMINO-4-(DIFLUOROMETHYLENE)CYCLOHEXENE AND CYCLOHEXANE CARBOXYLIC ACID AND USES THEREOF AS SELECTIVE INACTIVATORS OF HUMAN ORNITHINE AMINOTRANSFERASE (hOAT)
Disclosed are amino-substituted, halomethylene-substituted cyclohexene carboxylic acid compounds and amino-substituted. halomethylene-substituted cyclohexane carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating human ornithine aminotransferase (AO AT) activity, including methods for treating diseases or disorders associated with AO AT activity or expression such as cell proliferative diseases and disorders including cancer.
(S)-3-AMINO-4-(DIFLUOROMETHYLENE)CYCLOHEXENE AND CYCLOHEXANE CARBOXYLIC ACID AND USES THEREOF AS SELECTIVE INACTIVATORS OF HUMAN ORNITHINE AMINOTRANSFERASE (hOAT)
Disclosed are amino-substituted, halomethylene-substituted cyclohexene carboxylic acid compounds and amino-substituted. halomethylene-substituted cyclohexane carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating human ornithine aminotransferase (AO AT) activity, including methods for treating diseases or disorders associated with AO AT activity or expression such as cell proliferative diseases and disorders including cancer.
Method for producing dicarboxylic acid compound
It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: ##STR00001##
wherein R.sup.1 represents a C1-C6 alkyl group, R.sup.2 represents a C1-C6 alkyl group, and R.sup.3 represents a C1-C6 alkyl group.
Method for producing dicarboxylic acid compound
It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: ##STR00001##
wherein R.sup.1 represents a C1-C6 alkyl group, R.sup.2 represents a C1-C6 alkyl group, and R.sup.3 represents a C1-C6 alkyl group.
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID POLYMORPHS
The present invention is directed to 1-aminocyclopropane-1-carboxylic acid polymorphs and agricultural compositions thereof.
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID POLYMORPHS
The present invention is directed to 1-aminocyclopropane-1-carboxylic acid polymorphs and agricultural compositions thereof.
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID POLYMORPHS
The present invention is directed to 1-aminocyclopropane-1-carboxylic acid polymorphs and agricultural compositions thereof.
(S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and Related Compounds as GABA Aminotransferase Inactivators for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
(S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and Related Compounds as GABA Aminotransferase Inactivators for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
PROCESS FOR PREPARING SUBSTITUTED CYCLOHEXANE AMINO ACID ESTERS AND SPIROKETAL-SUBSTITUTED CYCLIC KETO-ENOLS
The present invention relates to a novel process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols, and to novel intermediates or starting compounds that are passed through or used in the process according to the invention.