Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.

Objects of the present invention are to provide an industrially applicable method for producing an optically active -amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ,-disubstituted -amino acid, and to provide an intermediate useful for the above production methods of an optically active -amino acid and an optically active ,-disubstituted -amino acid. The present invention provides a production method of an optically active -amino acid or a salt thereof, the production method comprising introducing a substituent into the carbon in the -amino acid moiety of a metal complex represented by the following Formula (1): ##STR00001##
by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure -amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

Objects of the present invention are to provide an industrially applicable method for producing an optically active -amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ,-disubstituted -amino acid, and to provide an intermediate useful for the above production methods of an optically active -amino acid and an optically active ,-disubstituted -amino acid. The present invention provides a production method of an optically active -amino acid or a salt thereof, the production method comprising introducing a substituent into the carbon in the -amino acid moiety of a metal complex represented by the following Formula (1): ##STR00001##
by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure -amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.

Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.