Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.

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Disclosed herein are substituted biaryl alkyl amide compounds, methods of synthesizing substituted biaryl alkyl amide compounds and methods of treating diseases and/or conditions with substituted biaryl alkyl amide compounds.

Disclosed herein are substituted biaryl alkyl amide compounds, methods of synthesizing substituted biaryl alkyl amide compounds and methods of treating diseases and/or conditions with substituted biaryl alkyl amide compounds.

Cannabinoid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof:

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wherein: R.sup.1 and R.sup.2 are independently H, alkyl, or alkenyl; R.sup.3 is alkyl, alkenyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl; R.sup.4 and R.sup.5 are independently a bond, alkylenyl, or alkenylenyl; each R.sup.6 and R.sup.7 is independently selected from the group consisting of OH, F, Cl, Br, I, (C.sub.1-C.sub.6)alkyl, alkoxy, amino, COOH, CONH.sub.2, SO.sub.3H, PO.sub.3H.sub.2, CN, SH, NO.sub.2 and CF.sub.3; and p and q are independently 0, 1, 2, 3, 4, or 5. Such compounds may be used to treat osteoporosis or multiple myeloma.

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

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This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

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Provided are: a nucleating agent for a polyolefin resin having an excellent crystal-forming effect; a nucleating agent composition for a polyolefin resin containing the nucleating agent; a polyolefin resin masterbatch; a polyolefin resin composition; a molded article of the composition; a film of the composition; a method of producing a porous film; and a package.

The nucleating agent contains a compound represented by Formula (1) below wherein M represents a monovalent to trivalent metal atom having a specific gravity of 4.0 or less, or the like; a represents 1 or 2; b represents 1 or 3; x represents an integer of 1 to 3; ax=2b is satisfied; and Z represents a group represented by Formula (2) or (3) below wherein * represents a position at which each group is linked with Z of Formula (1); Y represents a direct bond or an alkylene group having 1 to 4 carbon atoms; and R.sub.1 to R.sub.10 each independently represent a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group having 1 to 10 carbon atoms, or the like.

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Provided are: a nucleating agent for a polyolefin resin having an excellent crystal-forming effect; a nucleating agent composition for a polyolefin resin containing the nucleating agent; a polyolefin resin masterbatch; a polyolefin resin composition; a molded article of the composition; a film of the composition; a method of producing a porous film; and a package.

The nucleating agent contains a compound represented by Formula (1) below wherein M represents a monovalent to trivalent metal atom having a specific gravity of 4.0 or less, or the like; a represents 1 or 2; b represents 1 or 3; x represents an integer of 1 to 3; ax=2b is satisfied; and Z represents a group represented by Formula (2) or (3) below wherein * represents a position at which each group is linked with Z of Formula (1); Y represents a direct bond or an alkylene group having 1 to 4 carbon atoms; and R.sub.1 to R.sub.10 each independently represent a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group having 1 to 10 carbon atoms, or the like.

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The present invention provides compounds, compositions thereof, and methods of using the same.

The present invention provides compounds, compositions thereof, and methods of using the same.