The present application provides antibiotic compounds, as well as pharmaceutical compositions comprising these compounds, and methods of treating bacterial infections using these compounds

A rhein amide derivative and a preparation method and use thereof, and a drug for treating hepatocellular carcinoma (HCC) caused by a specific expression of RECQL4. The rhein amide derivative has a structure shown in any one of formulas I to IV. The rhein amide derivative has a relatively strong inhibitory effect on proliferation of HCC cells SNU-398 with RECQL4 high expression. Development of a novel anti-cancer drug for RECQL4 high expression-caused HCC and clinical personalized treatment of the RECQL4 high expression-caused HCC.

A rhein amide derivative and a preparation method and use thereof, and a drug for treating hepatocellular carcinoma (HCC) caused by a specific expression of RECQL4. The rhein amide derivative has a structure shown in any one of formulas I to IV. The rhein amide derivative has a relatively strong inhibitory effect on proliferation of HCC cells SNU-398 with RECQL4 high expression. Development of a novel anti-cancer drug for RECQL4 high expression-caused HCC and clinical personalized treatment of the RECQL4 high expression-caused HCC.

The invention describes phospho-amino pincer-type ligands, metal complexes thereof, and catalytic methods comprising such metal complexes for conversion of carbon dioxide to methanol, conversion of aldehydes into alcohols, conversion of aldehydes in the presence of a trifluoromethylation agent into trifluorinated secondary alcohols, cycloaddition of carbon dioxide to an epoxide to provide cyclic carbonates or preparation of an amide from the combination of an alcohol and an amine.

The invention describes phospho-amino pincer-type ligands, metal complexes thereof, and catalytic methods comprising such metal complexes for conversion of carbon dioxide to methanol, conversion of aldehydes into alcohols, conversion of aldehydes in the presence of a trifluoromethylation agent into trifluorinated secondary alcohols, cycloaddition of carbon dioxide to an epoxide to provide cyclic carbonates or preparation of an amide from the combination of an alcohol and an amine.

The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R.sup.3CONR.sup.1R.sup.2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R.sup.3CO.sub.2).sub.3—B—NHR.sup.1R.sup.2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.

The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R.sup.3CONR.sup.1R.sup.2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R.sup.3CO.sub.2).sub.3—B—NHR.sup.1R.sup.2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.

The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R.sup.3CONR.sup.1R.sup.2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R.sup.3CO.sub.2).sub.3—B—NHR.sup.1R.sup.2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.

Provided are: a compound that thickens or gelatinizes a fluid organic substance to a desired viscosity, or uniformly stabilizes a composition containing the fluid organic substance; a thickening/stabilizing agent including the compound; a thickened/stabilized composition including the thickening/stabilizing agent and a fluid organic substance; and a method for producing a thickened/stabilized composition. The compound according to the present invention is represented by Formula (1):
(R.sup.2—HNOC).sub.4-n—R.sup.1—(CONH—R.sup.3).sub.n  (1)
where R.sup.1 is a group resulting from removing four hydrogen atoms from the structural formula of benzene; R.sup.2 and R.sup.3 are different from each other and are each independently an aliphatic hydrocarbon group having 6 or more carbon atoms; and n represents an integer of 1 to 3.

Provided are: a compound that thickens or gelatinizes a fluid organic substance to a desired viscosity, or uniformly stabilizes a composition containing the fluid organic substance; a thickening/stabilizing agent including the compound; a thickened/stabilized composition including the thickening/stabilizing agent and a fluid organic substance; and a method for producing a thickened/stabilized composition. The compound according to the present invention is represented by Formula (1):
(R.sup.2—HNOC).sub.4-n—R.sup.1—(CONH—R.sup.3).sub.n  (1)
where R.sup.1 is a group resulting from removing four hydrogen atoms from the structural formula of benzene; R.sup.2 and R.sup.3 are different from each other and are each independently an aliphatic hydrocarbon group having 6 or more carbon atoms; and n represents an integer of 1 to 3.