A compound obtained through Michael addition reaction of an -aminoacetophenone skeleton-containing compound (I) represented by the following general formula (1) and a reactive compound (II) having a function as a Michael acceptor is used as a photopolymerization initiator. In the general formula (1), R.sub.1 represents an aliphatic group, R.sub.2 to R.sub.3 each independently represent an aliphatic group, etc., R.sub.4 to R.sub.7 each independently represent a hydrogen atom, X.sub.1 represents a single bond or a C1-6 alkylene group, X.sub.2 represents a carbonyl group, Y.sub.1 and Y.sub.2 represent a group represented by the following general formula (2). However, when Y.sub.1 and Y.sub.2 both have a structure represented by the general formula (2), X.sub.5 in at least one of them is NH. In the general formula (2), X.sub.3 and X.sub.4 each independently represent a linear or branched alkylene group having 2 to 6 carbon atoms, X.sub.5 represents a single bond, O or NH. ##STR00001##

A compound obtained through Michael addition reaction of an -aminoacetophenone skeleton-containing compound (I) represented by the following general formula (1) and a reactive compound (II) having a function as a Michael acceptor is used as a photopolymerization initiator. In the general formula (1), R.sub.1 represents an aliphatic group, R.sub.2 to R.sub.3 each independently represent an aliphatic group, etc., R.sub.4 to R.sub.7 each independently represent a hydrogen atom, X.sub.1 represents a single bond or a C1-6 alkylene group, X.sub.2 represents a carbonyl group, Y.sub.1 and Y.sub.2 represent a group represented by the following general formula (2). However, when Y.sub.1 and Y.sub.2 both have a structure represented by the general formula (2), X.sub.5 in at least one of them is NH. In the general formula (2), X.sub.3 and X.sub.4 each independently represent a linear or branched alkylene group having 2 to 6 carbon atoms, X.sub.5 represents a single bond, O or NH. ##STR00001##

Disclosed are compounds of formulae:

##STR00001##

and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are usefl for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

Disclosed are compounds of formulae:

##STR00001##

and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are usefl for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R.sub.1, R.sub.2, R.sub.3, R.sub.101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

##STR00001##

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R.sub.1, R.sub.2, R.sub.3, R.sub.101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

##STR00001##

Disclosed herein are compounds, compositions and methods for treating tumors, particularly tumors that metastasize, via inhibiting tumor cells-induced platelet aggregation. The compound of the present disclosure has the formula (I),

##STR00001##

wherein, n is 2 or 3.

A compound obtained through Michael addition reaction of an -aminoacetophenone skeleton-containing compound (I) represented by the following general formula (1) and a reactive compound (II) having a function as a Michael acceptor is used as a photopolymerization initiator. In the general formula (1), R.sub.1 represents an aliphatic group, R.sub.2 to R.sub.3 each independently represent an aliphatic group, etc., R.sub.4 to R.sub.7 each independently represent a hydrogen atom, X.sub.1 represents a single bond or a C1-6 alkylene group, X.sub.2 represents a carbonyl group, Y.sub.1 and Y.sub.2 represent a group represented by the following general formula (2). However, when Y.sub.1 and Y.sub.2 both have a structure represented by the general formula (2), X.sub.5 in at least one of them is NH. In the general formula (2), X.sub.3 and X.sub.4 each independently represent a linear or branched alkylene group having 2 to 6 carbon atoms, X.sub.5 represents a single bond, O or NH.

##STR00001##

A compound obtained through Michael addition reaction of an -aminoacetophenone skeleton-containing compound (I) represented by the following general formula (1) and a reactive compound (II) having a function as a Michael acceptor is used as a photopolymerization initiator. In the general formula (1), R.sub.1 represents an aliphatic group, R.sub.2 to R.sub.3 each independently represent an aliphatic group, etc., R.sub.4 to R.sub.7 each independently represent a hydrogen atom, X.sub.1 represents a single bond or a C1-6 alkylene group, X.sub.2 represents a carbonyl group, Y.sub.1 and Y.sub.2 represent a group represented by the following general formula (2). However, when Y.sub.1 and Y.sub.2 both have a structure represented by the general formula (2), X.sub.5 in at least one of them is NH. In the general formula (2), X.sub.3 and X.sub.4 each independently represent a linear or branched alkylene group having 2 to 6 carbon atoms, X.sub.5 represents a single bond, O or NH.

##STR00001##

The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

##STR00001##