The present invention relates to novel derivatives of cystobactamides of formula (Ib) and the use thereof for the treatment or prophylaxis of bacterial infections.

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The present invention relates to novel derivatives of cystobactamides of formula (Ib) and the use thereof for the treatment or prophylaxis of bacterial infections.

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Compounds and compositions comprising them are provided. The compounds and compositions are useful for inhibiting transport of heme across membranes in parasitic heme auxotrophic organisms, thereby limiting their growth or killing the parasites.

Compounds and compositions comprising them are provided. The compounds and compositions are useful for inhibiting transport of heme across membranes in parasitic heme auxotrophic organisms, thereby limiting their growth or killing the parasites.

Provided is a method of producing an aromatic amide derivative represented by Formula (I), which method includes a process a containing reacting an aniline derivative represented by Formula (II) with a carboxylic acid derivative represented by Formula (III) in the presence of a base to obtain an imide compound represented by Formula (IV) and a process b containing hydrolyzing the imide compound represented by Formula (IV) to obtain the aromatic amide derivative represented by Formula (I): ##STR00001##
wherein R.sup.1 represents a C.sub.1-C.sub.4 haloalkyl group, etc.; each of R.sup.2 and R.sup.3 independently represents a hydrogen atom, a halogen atom, etc.; R.sup.4 represents a hydrogen atom, a C.sub.1-C.sub.4 alkyl group, etc.; each of X.sup.1 and X.sup.2 independently represents a halogen atom, a C.sub.1-C.sub.4 haloalkyl group, etc.; and Q represents a C.sub.1-C.sub.4 alkyl group, a phenyl group, a pyridyl group, etc.

Provided is a method of producing an aromatic amide derivative represented by Formula (I), which method includes a process a containing reacting an aniline derivative represented by Formula (II) with a carboxylic acid derivative represented by Formula (III) in the presence of a base to obtain an imide compound represented by Formula (IV) and a process b containing hydrolyzing the imide compound represented by Formula (IV) to obtain the aromatic amide derivative represented by Formula (I): ##STR00001##
wherein R.sup.1 represents a C.sub.1-C.sub.4 haloalkyl group, etc.; each of R.sup.2 and R.sup.3 independently represents a hydrogen atom, a halogen atom, etc.; R.sup.4 represents a hydrogen atom, a C.sub.1-C.sub.4 alkyl group, etc.; each of X.sup.1 and X.sup.2 independently represents a halogen atom, a C.sub.1-C.sub.4 haloalkyl group, etc.; and Q represents a C.sub.1-C.sub.4 alkyl group, a phenyl group, a pyridyl group, etc.

The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.