C07C237/44

Uses of histone acetyltransferase activators

The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.

3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof

Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: ##STR00001## The compounds are useful for treating inflammatory and autoimmune diseases.

3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof

Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: ##STR00001## The compounds are useful for treating inflammatory and autoimmune diseases.

Aromatic amides having a fungicidal activity, their agronomic compositions and relative preparation method

Aromatic amides are described, having general formula (I): ##STR00001##
suitably substituted and having a high fungicidal activity, together with their use for controlling phytopathogenic fungi of important agricultural crops.

Aromatic amides having a fungicidal activity, their agronomic compositions and relative preparation method

Aromatic amides are described, having general formula (I): ##STR00001##
suitably substituted and having a high fungicidal activity, together with their use for controlling phytopathogenic fungi of important agricultural crops.

METHIONINE METABOLIC PATHWAY INHIBITORS
20230250086 · 2023-08-10 ·

The present invention provides novel inhibitors of cystathionin gamma synthase (CGS), their use as selective and non-selective herbicides, agricultural and non-agricultural herbicides, herbicides in integrated pest management, herbicides for gardening, clearing waste ground, clearing industrial or constructions sites, clearing railways and railway embankments, pesticide, fungicide, agricultural plant stimulant or antimicrobial agent. Also provided is a method for the control of undesired vegetation or clearing areas from the undesired vegetation comprising applying to the locus of said undesired vegetation, to the undesired plants or to a habitat thereof, a herbicidally effective amount of the compound of the present invention.

OLIGO-BENZAMIDE ANALOGS AND THEIR USE IN CANCER TREATMENT

The present disclosure compounds of the formulae:

##STR00001##

wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer.

Crystobactamides

The present invention provides cystobactamides of formula (I): R.sup.1—Ar.sup.1-L.sup.1-Ar.sup.2-L.sup.2-Ar.sup.3-L.sup.3-Ar.sup.4-L.sup.4-Ar.sup.5—R.sup.2 and the use thereof for the treatment or prophylaxis of bacterial infections.

Crystobactamides

The present invention provides cystobactamides of formula (I): R.sup.1—Ar.sup.1-L.sup.1-Ar.sup.2-L.sup.2-Ar.sup.3-L.sup.3-Ar.sup.4-L.sup.4-Ar.sup.5—R.sup.2 and the use thereof for the treatment or prophylaxis of bacterial infections.

NASAL FORMULATIONS OF METOCLOPRAMIDE

Nasal formulations of metoclopramide, which remain stable and/or colorless upon storage over a period of time, are provided. Also provided are methods of treating disorders treatable with metoclopramide, comprising administering the nasal solutions to patients in need thereof.