An alternative acetylation process for the synthesis of 5-acetamido-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A), an intermediate in the industrial preparation of non-ionic X-ray contrast agents, is described. The process can be performed on an industrial scale to produce Compound A with improved purity and improved yields compared to the established processes.

An alternative acetylation process for the synthesis of 5-acetamido-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A), an intermediate in the industrial preparation of non-ionic X-ray contrast agents, is described. The process can be performed on an industrial scale to produce Compound A with improved purity and improved yields compared to the established processes.

The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.

The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.

The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.

Compounds having general formula (I) with a high fungicidal activity are described, and their use for the control of phytopathogenic fungi of important agricultural crops.

Compounds having general formula (I) with a high fungicidal activity are described, and their use for the control of phytopathogenic fungi of important agricultural crops.

In some aspects, the present disclosure provides polyiodinated polyamino compounds that comprise a residue of a carboxylic-acid-substituted polyamino compound that is linked to a residue of a polyiodinated aromatic compound that comprises a plurality of vicinal diol groups, each having a proximal hydroxyl group and a distal hydroxyl group, wherein the polyiodinated polyamino compound is formed by a process that comprises reacting a single carboxylic acid group of the carboxylic-acid-substituted polyamino compound in an ester coupling reaction with a single hydroxyl group selected from the proximal and distal hydroxyl groups of the plurality of vicinal diol groups of the polyiodinated aromatic compound, thereby forming an ester group that links the residue of the carboxylic-acid-substituted polyamino compound to the residue of the polyiodinated aromatic compound. Other aspects of the present disclosure pertain to methods of making such polyiodinated polyamino compounds and systems employing such polyiodinated polyamino compounds.

In some aspects, the present disclosure provides polyiodinated polyamino compounds that comprise a residue of a carboxylic-acid-substituted polyamino compound that is linked to a residue of a polyiodinated aromatic compound that comprises a plurality of vicinal diol groups, each having a proximal hydroxyl group and a distal hydroxyl group, wherein the polyiodinated polyamino compound is formed by a process that comprises reacting a single carboxylic acid group of the carboxylic-acid-substituted polyamino compound in an ester coupling reaction with a single hydroxyl group selected from the proximal and distal hydroxyl groups of the plurality of vicinal diol groups of the polyiodinated aromatic compound, thereby forming an ester group that links the residue of the carboxylic-acid-substituted polyamino compound to the residue of the polyiodinated aromatic compound. Other aspects of the present disclosure pertain to methods of making such polyiodinated polyamino compounds and systems employing such polyiodinated polyamino compounds.