In one aspect, the present disclosure provides compounds of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure provides compounds of the formula (V): wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

##STR00001##

In one aspect, the present disclosure provides compounds of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure provides compounds of the formula (V): wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

##STR00001##

Process for the preparation of azidoperfluoroalkanes and azidopolyfluoroalkanes of general formula R.sub.FN.sub.3, where R.sub.F is chosen from a group containing C.sub.nF.sub.2n+1, C.sub.nF.sub.xH.sub.2n+1x, C.sub.nF.sub.xX.sub.2n+1x or R.sup.1CF.sub.2CF.sub.2, where n is an integer in the range of 1 to 10, x is an integer in the range of 2 to 20, X is Cl, Br, or I, R.sup.1 is C.sub.1-10 alkyl, ArO, ArS, imidazolyl, benzimidazolyl, or pyrazolyl and Ar is phenyl or substituted phenyl, by the reaction of electrophilic azidation reagent of general formula R.sup.2N.sub.3, where R.sup.2 is n-C.sub.4F.sub.9SO.sub.2, ArSO.sub.2, Br, I, with synthetic equivalent of polyfluoroalkylated carbanion of general formula [R.sub.F].sup..

Process for the preparation of azidoperfluoroalkanes and azidopolyfluoroalkanes of general formula R.sub.FN.sub.3, where R.sub.F is chosen from a group containing C.sub.nF.sub.2n+1, C.sub.nF.sub.xH.sub.2n+1x, C.sub.nF.sub.xX.sub.2n+1x or R.sup.1CF.sub.2CF.sub.2, where n is an integer in the range of 1 to 10, x is an integer in the range of 2 to 20, X is Cl, Br, or I, R.sup.1 is C.sub.1-10 alkyl, ArO, ArS, imidazolyl, benzimidazolyl, or pyrazolyl and Ar is phenyl or substituted phenyl, by the reaction of electrophilic azidation reagent of general formula R.sup.2N.sub.3, where R.sup.2 is n-C.sub.4F.sub.9SO.sub.2, ArSO.sub.2, Br, I, with synthetic equivalent of polyfluoroalkylated carbanion of general formula [R.sub.F].sup..

Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

In one aspect, the present disclosure provides compounds of the formula:

##STR00001##

wherein the variables are as defined herein.

In another aspect, the present disclosure provides compounds of the formula:

##STR00002##

wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

In one aspect, the present disclosure provides compounds of the formula:

##STR00001##

wherein the variables are as defined herein.

In another aspect, the present disclosure provides compounds of the formula:

##STR00002##

wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

The present invention relates to a cross-linkable composition comprising: i) a fluorinated ,-bis(propargyl) oligomer of formula (I): in which m is 1 to 100, e.g. 1 to 93, n is 2 to 150, e.g. 1 to 128, p is 0 to 2, preferably 0 or 1.75, and n, m and p are selected such that the fluorinated ,-bis(propargyl) oligomer of formula (I) has a number average molar mass Mn of 400 to 25000; ii) a cross-linking agent comprising at least three azide-N.sub.3 groups; and iii) optionally, a fluorinated oligomer comprising two terminal azide-N3 or fluorinated ,-bis(azide) oligomer groups. The invention also relates to a material comprising the click chemistry reaction product of the cross-linkable composition of the invention, to a method for preparing said material and to the uses thereof.

The present invention relates to a cross-linkable composition comprising: i) a fluorinated ,-bis(propargyl) oligomer of formula (I): in which m is 1 to 100, e.g. 1 to 93, n is 2 to 150, e.g. 1 to 128, p is 0 to 2, preferably 0 or 1.75, and n, m and p are selected such that the fluorinated ,-bis(propargyl) oligomer of formula (I) has a number average molar mass Mn of 400 to 25000; ii) a cross-linking agent comprising at least three azide-N.sub.3 groups; and iii) optionally, a fluorinated oligomer comprising two terminal azide-N3 or fluorinated ,-bis(azide) oligomer groups. The invention also relates to a material comprising the click chemistry reaction product of the cross-linkable composition of the invention, to a method for preparing said material and to the uses thereof.