The present invention relates to an improved process for the preparation of trifloxystrobin of formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity. ##STR00001##

Method for preparation of 5-alkylsalicylaldoximes with formula 1, where R is a C6-C16 alkyl group, consisting in that into a water-alcohol solvent system, p-alkylphenol, sodium hydroxide, chloroform and hydroxylamine are introduced, while in relation to the alkylphenol used, sodium hydroxide and chloroform are used in amounts from the stoichiometric amount to a 100% excess, and hydroxylamine is used in amounts from the stoichiometric amount to a 60% excess, and the reaction is carried out at a temperature of 60-75° C. for 1.5-4 h, and then, at a temperature of 20-30° C., the post-reaction mixture is acidified till the pH of the aqueous phase <7.0 is obtained, and next, an alcohol-water azeotrope is distilled off with an admixture of unreacted chloroform, the residue is mixed with a neutral C5-C10 hydrocarbon solvent, the layers are separated, and the solvent is distilled off from the organic phase.

Method for preparation of 5-alkylsalicylaldoximes with formula 1, where R is a C6-C16 alkyl group, consisting in that into a water-alcohol solvent system, p-alkylphenol, sodium hydroxide, chloroform and hydroxylamine are introduced, while in relation to the alkylphenol used, sodium hydroxide and chloroform are used in amounts from the stoichiometric amount to a 100% excess, and hydroxylamine is used in amounts from the stoichiometric amount to a 60% excess, and the reaction is carried out at a temperature of 60-75° C. for 1.5-4 h, and then, at a temperature of 20-30° C., the post-reaction mixture is acidified till the pH of the aqueous phase <7.0 is obtained, and next, an alcohol-water azeotrope is distilled off with an admixture of unreacted chloroform, the residue is mixed with a neutral C5-C10 hydrocarbon solvent, the layers are separated, and the solvent is distilled off from the organic phase.

A process for preparation of 3-Trifluoromethyl acetophenone oxime of formula I includes reacting an isomeric mixture of halo benzotrifluoride with Mg metal in an organic solvent in presence of a catalyst to obtain a Grignard complex. The Grignard complex is reacted with a ketene in hydrocarbon solvent in presence of transition metal ligand-acid complex to obtain an isomeric mixture of trifluoromethyl acetophenone. Finally, the isomeric mixture of trifluoromethyl acetophenone is reacted with hydroxylamine salt to obtain compound of formula I.

A process for preparation of 3-Trifluoromethyl acetophenone oxime of formula I includes reacting an isomeric mixture of halo benzotrifluoride with Mg metal in an organic solvent in presence of a catalyst to obtain a Grignard complex. The Grignard complex is reacted with a ketene in hydrocarbon solvent in presence of transition metal ligand-acid complex to obtain an isomeric mixture of trifluoromethyl acetophenone. Finally, the isomeric mixture of trifluoromethyl acetophenone is reacted with hydroxylamine salt to obtain compound of formula I.

A process for preparation of 3-Trifluoromethyl acetophenone oxime of formula I includes reacting an isomeric mixture of halo benzotrifluoride with Mg metal in an organic solvent in presence of a catalyst to obtain a Grignard complex. The Grignard complex is reacted with a ketene in hydrocarbon solvent in presence of transition metal ligand-acid complex to obtain an isomeric mixture of trifluoromethyl acetophenone. Finally, the isomeric mixture of trifluoromethyl acetophenone is reacted with hydroxylamine salt to obtain compound of formula I.

The present invention relates to an industrially feasible and economically viable process for the preparation of fluvoxamine maleate of formula I. ##STR00001##

The present invention relates to an industrially feasible and economically viable process for the preparation of fluvoxamine maleate of formula I. ##STR00001##

The present invention relates to an industrially feasible and economically viable process for the preparation of fluvoxamine maleate of formula I. ##STR00001##

The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates.

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