Patent classifications
C07C249/12
Process for preparing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester
This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes. ##STR00001##
Methods for preparing dihydroxyammonium 5,5′-bistetrazole-1,1′diolate
The present invention relates to a method for preparing dihydroxyammonium 5,5-bistetrazole-1,1-diolate. The method for preparing dihydroxyammonium 5,5-bistetrazole-1,1-diolate, according to one embodiment of the present invention, comprises the steps of: synthesizing 5,5-bistetrazole-1,1-diol dihydrate (1,1-BTO) from ditetrahydropyranyl diazidoglyoxime (THP-DAG) by using a hydrochloric acid (HCl) solution in a first solvent; and reacting 1,1-BTO with an amine solution so as to neutralize same and, simultaneously, obtaining dihydroxylammonium 5,5-bistetrazole-1,1-diolate (Thomas Klapotke explosive-50, TKX-50).
Methods for preparing dihydroxyammonium 5,5′-bistetrazole-1,1′diolate
The present invention relates to a method for preparing dihydroxyammonium 5,5-bistetrazole-1,1-diolate. The method for preparing dihydroxyammonium 5,5-bistetrazole-1,1-diolate, according to one embodiment of the present invention, comprises the steps of: synthesizing 5,5-bistetrazole-1,1-diol dihydrate (1,1-BTO) from ditetrahydropyranyl diazidoglyoxime (THP-DAG) by using a hydrochloric acid (HCl) solution in a first solvent; and reacting 1,1-BTO with an amine solution so as to neutralize same and, simultaneously, obtaining dihydroxylammonium 5,5-bistetrazole-1,1-diolate (Thomas Klapotke explosive-50, TKX-50).
Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer
Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.
Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer
Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.
PROCESS FOR THE PREPARATION OF EXAMETAZIME
The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex.
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PROCESS FOR THE PREPARATION OF EXAMETAZIME
The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex.
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PROCESS FOR THE PREPARATION OF EXAMETAZIME
The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex.
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Process for making Siponimod and intermediate thereof
The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates. ##STR00001##
Process for making Siponimod and intermediate thereof
The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates. ##STR00001##