An embodiment of the present invention provides a method for preparing a phthalonitrile-based compound, comprising: (a) feeding a mixture comprising a phthalic acid-based compound and a nitrile-based compound into a first reaction part to react; (b) transferring a resulting product of step (a) to a second reaction part connected to the first reaction part to react under the condition of 350 to 400° C.; and (c) obtaining a phthalonitrile-based compound at a discharge part connected to the second reaction part, wherein the second reaction part has a length in a fluid flow direction which is 10 times or more of a square root of an average cross-sectional area perpendicular to the fluid flow direction.

An embodiment of the present invention provides a method for preparing a phthalonitrile-based compound, comprising: (a) feeding a mixture comprising a phthalic acid-based compound and a nitrile-based compound into a first reaction part to react; (b) transferring a resulting product of step (a) to a second reaction part connected to the first reaction part to react under the condition of 350 to 400° C.; and (c) obtaining a phthalonitrile-based compound at a discharge part connected to the second reaction part, wherein the second reaction part has a length in a fluid flow direction which is 10 times or more of a square root of an average cross-sectional area perpendicular to the fluid flow direction.

Provided are a method and device for preparing adiponitrile. The method of the present disclosure comprises the steps of a first hydrocyanation reaction, an isomerization reaction and a second hydrocyanation reaction, wherein online Raman spectroscopy is used for detecting the content of a specific component in the system; and the reaction conditions are regulated based on the detection results, so as to achieve precise control of the materials in each step of the reaction system. The method of the present disclosure can reduce an amount of butadiene, thereby reducing the subsequent energy consumption needed for recycling butadiene and equipment investment after reaction; by monitoring the content of hydrocyanic acid in real time, the residue of hydrocyanic acid is reduced to a lower level, and the operation safety and the stability of a catalyst during reaction are improved; and the loss of the catalyst is reduced.

Provided are a method and device for preparing adiponitrile. The method of the present disclosure comprises the steps of a first hydrocyanation reaction, an isomerization reaction and a second hydrocyanation reaction, wherein online Raman spectroscopy is used for detecting the content of a specific component in the system; and the reaction conditions are regulated based on the detection results, so as to achieve precise control of the materials in each step of the reaction system. The method of the present disclosure can reduce an amount of butadiene, thereby reducing the subsequent energy consumption needed for recycling butadiene and equipment investment after reaction; by monitoring the content of hydrocyanic acid in real time, the residue of hydrocyanic acid is reduced to a lower level, and the operation safety and the stability of a catalyst during reaction are improved; and the loss of the catalyst is reduced.

Disclosed is a recovery method of a nitrile-based monomer including: supplying a feed stream including a nitrile-based monomer, a nitrogen compound, and water to a first distillation tower to separate the stream into a lower discharge stream and an upper discharge stream; condensing the upper discharge stream of the first distillation tower and supplying the condensed stream to a decanter to separate the stream into a water layer and an organic layer; supplying an organic layer stream discharged from the decanter to a second distillation tower to separate the stream into a lower discharge stream and an upper discharge stream; and splitting a part of the upper discharge stream from the second distillation tower and refluxing the split stream to the second distillation tower.

Disclosed is a recovery method of a nitrile-based monomer including: supplying a feed stream including a nitrile-based monomer, a nitrogen compound, and water to a first distillation tower to separate the stream into a lower discharge stream and an upper discharge stream; condensing the upper discharge stream of the first distillation tower and supplying the condensed stream to a decanter to separate the stream into a water layer and an organic layer; supplying an organic layer stream discharged from the decanter to a second distillation tower to separate the stream into a lower discharge stream and an upper discharge stream; and splitting a part of the upper discharge stream from the second distillation tower and refluxing the split stream to the second distillation tower.

Disclosed is a recovery method of a nitrile-based monomer including: supplying a feed stream including a nitrile-based monomer, a nitrogen compound, and water to a first distillation tower to separate the stream into a lower discharge stream and an upper discharge stream; condensing the upper discharge stream of the first distillation tower and supplying the condensed stream to a decanter to separate the stream into a water layer and an organic layer; supplying an organic layer stream discharged from the decanter to a second distillation tower to separate the stream into a lower discharge stream and an upper discharge stream; and splitting a part of the upper discharge stream from the second distillation tower and refluxing the split stream to the second distillation tower.

The present invention reports the obtaining of carbonyl compounds and derivatives, through syntheses with high yield and purity, providing anti-humoral active principles with selective antiproliferative properties and anti-metastatic activity.

The present invention refers to the development of new polyfunctional push-pull butadienes and their O and C-prenylated, benzoylated and iodide derivatives, with high electronic conjugation in the lateral chain. These compounds exhibit high anti-tumor selectivity, causing cell death by apoptosis, also show anti-metastatic and non-mutagenic properties in the experimental studies performed.

The present invention reports the obtaining of carbonyl compounds and derivatives, through syntheses with high yield and purity, providing anti-humoral active principles with selective antiproliferative properties and anti-metastatic activity.

The present invention refers to the development of new polyfunctional push-pull butadienes and their O and C-prenylated, benzoylated and iodide derivatives, with high electronic conjugation in the lateral chain. These compounds exhibit high anti-tumor selectivity, causing cell death by apoptosis, also show anti-metastatic and non-mutagenic properties in the experimental studies performed.

A method for producing a purified phthalonitrile is described. The method involves reacting ammonia, oxygen, and xylene in the presence of a catalyst to obtain a product gas containing a phthalonitrile and a cyanobenzamide and then contacting the reaction product gas with an organic solvent to obtain a collection liquid. The collection liquid is distilled by a high boiling point fraction-separating column to obtain a gas that contains the phthalonitrile and the organic solvent from the column top, and to obtain a bottom liquid that contains a cyanobenzamide from the column bottom. The bottom liquid has a phthalonitrile content of 90% by mass or less. The bottom liquid is subjected to combustion, while being kept in a liquid state, and the purified phthalonitrile is obtained by removing the organic solvent from the gas that has been obtained from the column top.