A solidification or crystallization method is disclosed, which includes providing at least a first organic compound and at least one volatile co-former organic compound. A mixture of at least the first organic compound and the co-former organic compound is formed, wherein either the first organic compound or the volatile co-former organic compound includes a hydrogen acceptor moiety and the other includes a hydrogen donor moiety, thereby allowing the formation of hydrogen bonds between the first organic compound and the volatile co-former organic compound. The mixture is allowed to stand for sufficient time for the mixture to liquify at a temperature below that of the melting points of the components, thereby forming a liquid mixture. The volatile co-former organic compound is allowed to evaporate, thereby resulting in crystallization of at least the first organic compound. The method can be a co-crystallization method if there are two organic compounds.

A solidification or crystallization method is disclosed, which includes providing at least a first organic compound and at least one volatile co-former organic compound. A mixture of at least the first organic compound and the co-former organic compound is formed, wherein either the first organic compound or the volatile co-former organic compound includes a hydrogen acceptor moiety and the other includes a hydrogen donor moiety, thereby allowing the formation of hydrogen bonds between the first organic compound and the volatile co-former organic compound. The mixture is allowed to stand for sufficient time for the mixture to liquify at a temperature below that of the melting points of the components, thereby forming a liquid mixture. The volatile co-former organic compound is allowed to evaporate, thereby resulting in crystallization of at least the first organic compound. The method can be a co-crystallization method if there are two organic compounds.

The present invention relates to the technical field of acetonitrile refining, and in particular, to an acetonitrile purification process for an ultrahigh performance liquid chromatography-mass spectrometer. According to the acetonitrile purification process provided by the present invention, the production cost may be reduced and the yield may be increased to reach 95% or more while the quality of the chromatographic pure acetonitrile is further improved to reach the UPLC-MS level; and an industrial UPLC-MS level acetonitrile purification and preparation method provided by the present invention has the advantages of simple operation, low cost, safety, high efficiency and capability of realizing large-scale industrial production.

The present invention relates to the technical field of acetonitrile refining, and in particular, to an acetonitrile purification process for an ultrahigh performance liquid chromatography-mass spectrometer. According to the acetonitrile purification process provided by the present invention, the production cost may be reduced and the yield may be increased to reach 95% or more while the quality of the chromatographic pure acetonitrile is further improved to reach the UPLC-MS level; and an industrial UPLC-MS level acetonitrile purification and preparation method provided by the present invention has the advantages of simple operation, low cost, safety, high efficiency and capability of realizing large-scale industrial production.

The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C.sub.1-10 alkyl or C.sub.1-10alkyloxy, C.sub.2-10 alkenyl or C.sub.2-10 alkenyloxy, C.sub.2-10 alkynyl or C.sub.2-10 alkynyloxy, C.sub.3-10 cycloalkyl or C.sub.3-10 cycloalkyloxy, C.sub.3-10 heterocycloalkyl or C.sub.3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

##STR00001##

The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C.sub.1-10 alkyl or C.sub.1-10alkyloxy, C.sub.2-10 alkenyl or C.sub.2-10 alkenyloxy, C.sub.2-10 alkynyl or C.sub.2-10 alkynyloxy, C.sub.3-10 cycloalkyl or C.sub.3-10 cycloalkyloxy, C.sub.3-10 heterocycloalkyl or C.sub.3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

##STR00001##

High purity 2-naphthylacetonitrile with fewer impurities can be used as a starting material or intermediate for synthesizing various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile, may include: subjecting 2′-acetonaphthone to a Willgerodt reaction in the presence of an additive where necessary, and hydrolyzing the obtained amide compound to give 2-naphthylacetic acid; and reacting the 2-naphthylacetic acid obtained in the subjecting, a halogenating agent and sulfamide in the presence of a catalyst as necessary in an organic solvent to give 2-naphthylacetonitrile.

High purity 2-naphthylacetonitrile with fewer impurities can be used as a starting material or intermediate for synthesizing various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile, may include: subjecting 2′-acetonaphthone to a Willgerodt reaction in the presence of an additive where necessary, and hydrolyzing the obtained amide compound to give 2-naphthylacetic acid; and reacting the 2-naphthylacetic acid obtained in the subjecting, a halogenating agent and sulfamide in the presence of a catalyst as necessary in an organic solvent to give 2-naphthylacetonitrile.

Provided herein are processes for purifying TCH in a feed stream, such as an adiponitrile process stream. The processes include a first separating step of separating the adiponitrile process stream to form a first overhead stream comprising low-boiling components and high-boiling components and a first bottoms stream comprising high-boiling components. The processes also include a second separating step of separating the first overhead stream in one or more distillation columns to form a lights stream comprising low-boiling components, a heavies stream comprising high-boiling components, and a TCH stream.

Provided herein are processes for purifying TCH in a feed stream, such as an adiponitrile process stream. The processes include a first separating step of separating the adiponitrile process stream to form a first overhead stream comprising low-boiling components and high-boiling components and a first bottoms stream comprising high-boiling components. The processes also include a second separating step of separating the first overhead stream in one or more distillation columns to form a lights stream comprising low-boiling components, a heavies stream comprising high-boiling components, and a TCH stream.