Compounds are provided having the following structure:

##STR00001##

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, G.sup.1, G.sup.2 and G.sup.3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Compounds are provided having the following structure:

##STR00001##

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, G.sup.1, G.sup.2 and G.sup.3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Tertiary amine catalysts having isocyanate reactive groups capable of forming thermally stable covalent bonds able to withstand temperatures from 120 C. and higher and up to 250 C. are disclosed. These catalyst can be used to produce polyurethane foam having the following desirable characteristics: a) very low chemical emissions over a wide range of environmental conditions and isocyanate indexes (e.g., indexes as low as 65 but higher than 60); b) sufficient hydrolytic stability to maintain the catalyst covalently bound to foam without leaching of tertiary amine catalyst when foam is exposed to water or aqueous solutions even at temperatures higher than ambient (temperature range 25 C. to 90 C.); and c) stable contact interface between the polyurethane polymer and other polymers (for example polycarbonate) with minimal migration of tertiary amine catalyst from polyurethane polymer to other polymers yielding no noticeable polymer deterioration at the point of contact even under conditions of heat and humidity.

Tertiary amine catalysts having isocyanate reactive groups capable of forming thermally stable covalent bonds able to withstand temperatures from 120 C. and higher and up to 250 C. are disclosed. These catalyst can be used to produce polyurethane foam having the following desirable characteristics: a) very low chemical emissions over a wide range of environmental conditions and isocyanate indexes (e.g., indexes as low as 65 but higher than 60); b) sufficient hydrolytic stability to maintain the catalyst covalently bound to foam without leaching of tertiary amine catalyst when foam is exposed to water or aqueous solutions even at temperatures higher than ambient (temperature range 25 C. to 90 C.); and c) stable contact interface between the polyurethane polymer and other polymers (for example polycarbonate) with minimal migration of tertiary amine catalyst from polyurethane polymer to other polymers yielding no noticeable polymer deterioration at the point of contact even under conditions of heat and humidity.

A process for converting caprolactam to aminocapronitrile (ACN), the process comprising contacting a caprolactam feed stream with ammonia to produce a first crude product stream; separating the first crude product stream to produce an intermediate product stream comprising ACN and caprolactam recovery stream; and purifying the intermediate product stream to produce a purified product stream comprising greater than 95 wt % aminocapronitrile.

A process for converting caprolactam to aminocapronitrile (ACN), the process comprising contacting a caprolactam feed stream with ammonia to produce a first crude product stream; separating the first crude product stream to produce an intermediate product stream comprising ACN and caprolactam recovery stream; and purifying the intermediate product stream to produce a purified product stream comprising greater than 95 wt % aminocapronitrile.

A process for regenerating a deactivated catalyst, the process comprising contacting a deactivated aluminosilicate zeolite catalyst comprising a nitrogen-containing contaminant with an oxidant to provide a regenerated catalyst comprising less than 0.5% contaminant and a regeneration by-product stream comprising nitrogen.

A process for regenerating a deactivated catalyst, the process comprising contacting a deactivated aluminosilicate zeolite catalyst comprising a nitrogen-containing contaminant with an oxidant to provide a regenerated catalyst comprising less than 0.5% contaminant and a regeneration by-product stream comprising nitrogen.

A photoacid generator compound having Formula (I):

##STR00001##

wherein, EWG, Y, R, and M.sup.+ are the same as described in the specification.