The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

A preparation method of 1-(4-aminophenyl)cyclopentanecarbonitrile includes the following steps: step 1: in the presence of Li.sub.2CuCl.sub.4, adding a nitrochlorobenzene-zinc reagent dropwise to a 1-chlorocyclopentanecarbonitrile solution to prepare a compound 1-(4-nitrophenyl)cyclopentanecarbonitrile; and step 2: subjecting the compound 1-(4-nitrophenyl)cyclopentanecarbonitrile obtained in step 1 to a nitroreduction reaction under the action of a catalyst to prepare the compound 1-(4-aminophenyl)cyclopentanecarbonitrile. The preparation method involves cheap and easily-available raw materials, mild reaction conditions, and convenient operations, leads to high yield, and is environmentally-friendly and suitable for industrial large-scale production.

A preparation method of 1-(4-aminophenyl)cyclopentanecarbonitrile includes the following steps: step 1: in the presence of Li.sub.2CuCl.sub.4, adding a nitrochlorobenzene-zinc reagent dropwise to a 1-chlorocyclopentanecarbonitrile solution to prepare a compound 1-(4-nitrophenyl)cyclopentanecarbonitrile; and step 2: subjecting the compound 1-(4-nitrophenyl)cyclopentanecarbonitrile obtained in step 1 to a nitroreduction reaction under the action of a catalyst to prepare the compound 1-(4-aminophenyl)cyclopentanecarbonitrile. The preparation method involves cheap and easily-available raw materials, mild reaction conditions, and convenient operations, leads to high yield, and is environmentally-friendly and suitable for industrial large-scale production.

The present invention provides a production method for dicyanocyclohexane, including a step of obtaining dicyanocyclohexane by reacting cyclohexanedicarboxylic acid and/or a salt thereof, or a heated concentrate of an aqueous ammonia solution of cyclohexanedicarboxylic acid with ammonia in a solvent having a boiling point equal to or higher than a reaction temperature.

The present invention provides a production method for dicyanocyclohexane, including a step of obtaining dicyanocyclohexane by reacting cyclohexanedicarboxylic acid and/or a salt thereof, or a heated concentrate of an aqueous ammonia solution of cyclohexanedicarboxylic acid with ammonia in a solvent having a boiling point equal to or higher than a reaction temperature.

The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

An electrolyte including one or more nitrile benzoquinone compounds, and the nitrile benzoquinone compound is selected from the group consisting of the compounds represented by formula I, formula II, and formula III:

##STR00001##

The substituents R.sub.1 to R.sub.9 are each independently selected from the group consisting of hydrogen, a C.sub.2 to C.sub.12 ether group, a C.sub.1 to C.sub.12 alkoxy group, halogen, a C.sub.1 to C.sub.12 alkyl group, a C.sub.2 to C.sub.12 alkenyl group, a C.sub.2 to C.sub.12 alkynyl group, and a C.sub.6 to C.sub.26 aryl group. The electrolyte can form a stable protective film on a cathode, thereby increasing the cycle capacity retention rate and high temperature storage performance of an electrochemical device.

An electrolyte including one or more nitrile benzoquinone compounds, and the nitrile benzoquinone compound is selected from the group consisting of the compounds represented by formula I, formula II, and formula III:

##STR00001##

The substituents R.sub.1 to R.sub.9 are each independently selected from the group consisting of hydrogen, a C.sub.2 to C.sub.12 ether group, a C.sub.1 to C.sub.12 alkoxy group, halogen, a C.sub.1 to C.sub.12 alkyl group, a C.sub.2 to C.sub.12 alkenyl group, a C.sub.2 to C.sub.12 alkynyl group, and a C.sub.6 to C.sub.26 aryl group. The electrolyte can form a stable protective film on a cathode, thereby increasing the cycle capacity retention rate and high temperature storage performance of an electrochemical device.