The present disclosure pertains to amino cyclohexanone compounds, pharmaceutical compositions containing same and methods of treating depression, pain, inflammation, and other clinical indications.

The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.

The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.

A compound represented by Formula (I) is provided:

##STR00001##

In Formula (I), R.sup.3, R.sup.4, and R.sup.5 each independently represent an electron-withdrawing group; R.sup.1, R.sup.2, R.sup.6, and R.sup.7 each independently represent a hydrogen atom, a heterocyclic group, a halogen atom, a nitro group, a cyano group, a hydroxy group, a thiol group, a carboxy group, —SCF.sub.3, —SF.sub.5, —SF.sub.3, —SO.sub.3H, —SO.sub.2H, an aliphatic hydrocarbon group having 1 to 25 carbon atoms which may have a substituent, or an aromatic hydrocarbon group having 6 to 18 carbon atoms which may have a substituent; and R.sup.1 and R.sup.2, R.sup.1 and R.sup.6, R.sup.6 and R.sup.7, and R.sup.4 and R.sup.5 may be linked to each other to form a ring.

A compound represented by Formula (I) is provided:

##STR00001##

In Formula (I), R.sup.3, R.sup.4, and R.sup.5 each independently represent an electron-withdrawing group; R.sup.1, R.sup.2, R.sup.6, and R.sup.7 each independently represent a hydrogen atom, a heterocyclic group, a halogen atom, a nitro group, a cyano group, a hydroxy group, a thiol group, a carboxy group, —SCF.sub.3, —SF.sub.5, —SF.sub.3, —SO.sub.3H, —SO.sub.2H, an aliphatic hydrocarbon group having 1 to 25 carbon atoms which may have a substituent, or an aromatic hydrocarbon group having 6 to 18 carbon atoms which may have a substituent; and R.sup.1 and R.sup.2, R.sup.1 and R.sup.6, R.sup.6 and R.sup.7, and R.sup.4 and R.sup.5 may be linked to each other to form a ring.

A compound having a molecular weight of 3000 or less and a partial structure represented by Formula (X) is provided:

##STR00001##

In Formula (X), a ring W.sup.1 represents a ring structure having at least one double bond as a constituent element of the ring and having no aromaticity; and R.sup.3 represents a heterocyclic group, a halogen atom, a nitro group, a cyano group, a hydroxy group, a thiol group, a carboxy group, —SF.sub.5, —SF.sub.3, —SO.sub.3H, —SO.sub.2H, an aliphatic hydrocarbon group having 1 to 25 carbon atoms which may have a substituent, or an aromatic hydrocarbon group having 6 to 18 carbon atoms which may have a substituent.

A compound having a molecular weight of 3000 or less and a partial structure represented by Formula (X) is provided:

##STR00001##

In Formula (X), a ring W.sup.1 represents a ring structure having at least one double bond as a constituent element of the ring and having no aromaticity; and R.sup.3 represents a heterocyclic group, a halogen atom, a nitro group, a cyano group, a hydroxy group, a thiol group, a carboxy group, —SF.sub.5, —SF.sub.3, —SO.sub.3H, —SO.sub.2H, an aliphatic hydrocarbon group having 1 to 25 carbon atoms which may have a substituent, or an aromatic hydrocarbon group having 6 to 18 carbon atoms which may have a substituent.

The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C.sub.1-10 alkyl or C.sub.1-10alkyloxy, C.sub.2-10 alkenyl or C.sub.2-10 alkenyloxy, C.sub.2-10 alkynyl or C.sub.2-10 alkynyloxy, C.sub.3-10 cycloalkyl or C.sub.3-10 cycloalkyloxy, C.sub.3-10 heterocycloalkyl or C.sub.3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

##STR00001##

The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C.sub.1-10 alkyl or C.sub.1-10alkyloxy, C.sub.2-10 alkenyl or C.sub.2-10 alkenyloxy, C.sub.2-10 alkynyl or C.sub.2-10 alkynyloxy, C.sub.3-10 cycloalkyl or C.sub.3-10 cycloalkyloxy, C.sub.3-10 heterocycloalkyl or C.sub.3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

##STR00001##

The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C.sub.1-10 alkyl or C.sub.1-10alkyloxy, C.sub.2-10 alkenyl or C.sub.2-10 alkenyloxy, C.sub.2-10 alkynyl or C.sub.2-10 alkynyloxy, C.sub.3-10 cycloalkyl or C.sub.3-10 cycloalkyloxy, C.sub.3-10 heterocycloalkyl or C.sub.3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

##STR00001##