Patent classifications
C07C259/06
Compounds useful for treating a <i>Mannheimia haemolytica </i>or <i>Histophilus somni </i>infection
The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD). ##STR00001##
Compounds useful for treating a <i>Mannheimia haemolytica </i>or <i>Histophilus somni </i>infection
The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD). ##STR00001##
Benzoylglycine derivatives and methods of making and using same
Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds. ##STR00001##
Benzoylglycine derivatives and methods of making and using same
Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds. ##STR00001##
RIP1 Inhibitors
The invention provides amides that inhibit cellular necrosis including corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
Photoswitchable HDAC Inhibitors
This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
Photoswitchable HDAC Inhibitors
This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
COMPOUNDS FOR TREATING INFECTIONS
The invention relates to hydrazide compounds and their use in medicine, particularly in treating and/or preventing infections caused by a fungus.
COMPOUNDS FOR TREATING INFECTIONS
The invention relates to hydrazide compounds and their use in medicine, particularly in treating and/or preventing infections caused by a fungus.
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.