To provide a novel class-A GPCR antagonist, a production method therefor, or a novel compound that interacts with a Na.sup.+-water cluster binding site of a class-A GPCR. Used is a compound or a salt thereof comprising a structure comprising a class-A GPCR-binding compound linked to a functional group that can bind to a Na.sup.+-water cluster binding site of the class-A GPCR. Also used is a method for producing a class-A GPCR antagonist, comprising the step of linking one compound with another compound that can bind to a Na.sup.+-water cluster binding site of the class-A GPCR.

To provide a novel class-A GPCR antagonist, a production method therefor, or a novel compound that interacts with a Na.sup.+-water cluster binding site of a class-A GPCR. Used is a compound or a salt thereof comprising a structure comprising a class-A GPCR-binding compound linked to a functional group that can bind to a Na.sup.+-water cluster binding site of the class-A GPCR. Also used is a method for producing a class-A GPCR antagonist, comprising the step of linking one compound with another compound that can bind to a Na.sup.+-water cluster binding site of the class-A GPCR.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

The present invention relates to a process for the preparation of substituted 4-(N-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I). ##STR00001##

The present invention relates to a process for the preparation of substituted 4-(N-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I). ##STR00001##

This disclosure includes pesticidal compounds, compositions, and related agricultural methods.

Compounds and methods for the treatment of a bacterial infection or the potentiation of an antibiotic in treating a bacterial infection are described herein.

In one aspect, aryl carboximidamide compounds, comprising a carboximidamide molecular substructure, and modulating mammalian sirtuin enzymes (SIRT1-7) are described herein, and, in particular, to compounds for the modulation of SIRT3. Novel small molecules that modulate sirtuin activities were developed employing DNA encoded Library technology (ELT). Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition.

In one aspect, aryl carboximidamide compounds, comprising a carboximidamide molecular substructure, and modulating mammalian sirtuin enzymes (SIRT1-7) are described herein, and, in particular, to compounds for the modulation of SIRT3. Novel small molecules that modulate sirtuin activities were developed employing DNA encoded Library technology (ELT). Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition.