Disclosed herein is a salt, a crystalline anhydrous form, a hydrate, a solvate, or a co-crystal of a free base compound 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[(2-hydroxyethanesulfonyl)amino]benzamide (Compound A); method of preparation, pharmaceutical compositions, and method of treating a disease mediated by a motor protein kinesin family member 18A (KIF18A) inhibition, wherein said disease is a neoplastic disease, including a cancer or a tumor.

An EP4 antagonist represented by formula I, which specifically comprises a crystal form thereof, a pharmaceutically acceptable salt or crystal form thereof, a preparation method therefor, a composition containing same, and a medical use of a related compound. The structure of formula I is shown below:

##STR00001##

An EP4 antagonist represented by formula I, which specifically comprises a crystal form thereof, a pharmaceutically acceptable salt or crystal form thereof, a preparation method therefor, a composition containing same, and a medical use of a related compound. The structure of formula I is shown below:

##STR00001##

This invention provides a blocking agent dissociation catalyst for blocked isocyanates comprising an onium salt represented by the following formula (1):

##STR00001##

wherein n, R.sup.1, R.sup.2, R.sup.3, A, X, a, b, and Q.sup.+ are as defined in the specification.

This invention provides a blocking agent dissociation catalyst for blocked isocyanates comprising an onium salt represented by the following formula (1):

##STR00001##

wherein n, R.sup.1, R.sup.2, R.sup.3, A, X, a, b, and Q.sup.+ are as defined in the specification.

Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

The original abstract is amended to A method for self-catalytic directional degradation of polyurethane material includes performing a crushing step, performing a mixing step, performing a degradation step, and performing a heating and pressure reduction step. In the crushing step, the polyurethane material is crushed to form several polyurethane particles. In a mixing step, the several polyurethane particles are mixed with an alcoholamine compound to form a degradation system, and the alcoholamine compound has a structure represented by formula (I) or formula (II), of which each symbol is defined in the specification. In the degradation step, the degradation system is degraded at a reaction temperature to obtain an intermediate product. In the heating and pressure reduction step, the intermediate product is under the reaction temperature and a reduced reaction pressure to remove an excess portion of the alcoholamine compound, so as to obtain a polyol.

The original abstract is amended to A method for self-catalytic directional degradation of polyurethane material includes performing a crushing step, performing a mixing step, performing a degradation step, and performing a heating and pressure reduction step. In the crushing step, the polyurethane material is crushed to form several polyurethane particles. In a mixing step, the several polyurethane particles are mixed with an alcoholamine compound to form a degradation system, and the alcoholamine compound has a structure represented by formula (I) or formula (II), of which each symbol is defined in the specification. In the degradation step, the degradation system is degraded at a reaction temperature to obtain an intermediate product. In the heating and pressure reduction step, the intermediate product is under the reaction temperature and a reduced reaction pressure to remove an excess portion of the alcoholamine compound, so as to obtain a polyol.