The present invention relates to a compound, 1-[(5-chloro-2-pyridinyl)methyl]-3-{2,6-dichloro-4-[(2S)-1,1,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea, or a pharmaceutically acceptable salt thereof.

The present disclosure relates to a t-butylketone binaphthol derivative and a method of preparing the same, the t-butylketone binaphthol derivative being a high-efficiency chiral extracting agent which has a very high chiral selectivity enabling to extract an amino acid from an aqueous solution phase to an organic layer and to facilitate its hydrolysis, and enabling a continuous reuse of the organic layer.

The present disclosure relates to a t-butylketone binaphthol derivative and a method of preparing the same, the t-butylketone binaphthol derivative being a high-efficiency chiral extracting agent which has a very high chiral selectivity enabling to extract an amino acid from an aqueous solution phase to an organic layer and to facilitate its hydrolysis, and enabling a continuous reuse of the organic layer.

The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

A carbamate compound represented by the following formula (0).

##STR00001##

wherein l is 0 or 1, m is an integer of 1 to 4, n is an integer of 1 to 4, R.sup.1 and R.sup.2 are substituents having a R.sup.10CR.sub.2 structure, R.sup.3 is a hydrogen atom or a substituent having a R.sup.10CR.sub.2 structure, R.sup.4 is a substituent selected from a substituent having a R.sup.10CR.sub.2 structure, a substituent having a R.sup.10At.sup.16 structure, and a substituent having a R.sup.10.sub.2At.sup.15 structure, At.sup.15 is a Group 15 atom, At.sup.16 is a Group 16 atom, R and R.sup.10 are each a group containing an atom selected from carbon, hydrogen, and Groups 15, 16, and 17 elements, which has 0 to 17 carbon atoms and 0 to 4 heteroatoms, R.sup.1 to R.sup.4 and R may bond to each other to form a monocyclic or polycyclic ring, and R and R.sup.10 may bond to each other to form a monocyclic ring, a polycyclic ring, or a multiple bond.

A carbamate compound represented by the following formula (0).

##STR00001##

wherein l is 0 or 1, m is an integer of 1 to 4, n is an integer of 1 to 4, R.sup.1 and R.sup.2 are substituents having a R.sup.10CR.sub.2 structure, R.sup.3 is a hydrogen atom or a substituent having a R.sup.10CR.sub.2 structure, R.sup.4 is a substituent selected from a substituent having a R.sup.10CR.sub.2 structure, a substituent having a R.sup.10At.sup.16 structure, and a substituent having a R.sup.10.sub.2At.sup.15 structure, At.sup.15 is a Group 15 atom, At.sup.16 is a Group 16 atom, R and R.sup.10 are each a group containing an atom selected from carbon, hydrogen, and Groups 15, 16, and 17 elements, which has 0 to 17 carbon atoms and 0 to 4 heteroatoms, R.sup.1 to R.sup.4 and R may bond to each other to form a monocyclic or polycyclic ring, and R and R.sup.10 may bond to each other to form a monocyclic ring, a polycyclic ring, or a multiple bond.