The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

The synthesis of a range of pentylbezene-1,3-diol compounds of formula I is disclosed. These compounds bind to cannabinoid 1 and 2 receptors (CB1 and CB2), and are thus presumed to be useful in modulating the activity of such receptors. Accordingly, the use of such synthetic cannabinoids in the treatment of various disorders mediated by CB1 and CB2 is contemplated.

The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

##STR00001##

Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

##STR00001##

The present technology relates to methods for the synthesis of a lithium single-ion monomer which comprises simultaneously reacting a sulfonyl chloride compound with i) a fluorinated sulfonamide compound and ii) a compound that is suitable to act as a quenching base and a lithium cation source. The simultaneous reaction of sulfonyl chloride with the fluorinated sulfonamide compound and the compound that is suitable to act as a quenching base and a lithium cation source yields the single-ion monomer.

The present technology relates to methods for the synthesis of a lithium single-ion monomer which comprises simultaneously reacting a sulfonyl chloride compound with i) a fluorinated sulfonamide compound and ii) a compound that is suitable to act as a quenching base and a lithium cation source. The simultaneous reaction of sulfonyl chloride with the fluorinated sulfonamide compound and the compound that is suitable to act as a quenching base and a lithium cation source yields the single-ion monomer.

The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.