Polymer conjugates are provided that are capable of mimicking functions of natural proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates of the invention have utility in treating a subject suffering soft tissue conditions. Also provided are simple and scalable chemical processes for the preparation of the polymer conjugates of the invention.

Polymer conjugates are provided that are capable of mimicking functions of natural proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates of the invention have utility in treating a subject suffering soft tissue conditions. Also provided are simple and scalable chemical processes for the preparation of the polymer conjugates of the invention.

K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.

K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.

Systems and processes for hydrotreating, splitting, and extracting a gasoil feed to produce a saturate-rich feedstock for olefin pyrolysis are provided. A gasoil feed is provided to a hydrotreating section to produce an ultralow sulfur distillate (ULSD) stream. The ULSD stream is provided to a splitter section to produce a light distillate stream and a heavy bottom stream. The light distillate stream is provided to an extraction section to produce an aromatic-rich extract phase and a saturate-rich raffinate phase. The raffinate phase is mixed with the heavy bottom stream to produce an olefin pyrolysis feedstock having a reduced BMCI as compared to the gasoil feed stream and the ULSD stream.

The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb):

##STR00001## ##STR00002##

which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb):

##STR00001## ##STR00002##

which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.

K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.

An electrolyte including: a lithium salt, a non-aqueous solvent, an alkyl sulfonate compound represented by Formula 2, and an unsaturated sulfone compound represented by Formula 3:

##STR00001## wherein, in Formula 2, Q.sub.1 and Q.sub.2 are each independently a substituted or unsubstituted C.sub.1-C.sub.20 alkyl group, and in Formula 3, Q.sub.3 and Q.sub.4 are each independently a group represented by -(L.sub.1)-(R.sub.1), a vinyl group, an allyl group, or a substituted or unsubstituted C.sub.1-C.sub.20 alkyl group, and at least one of Q.sub.3 or Q.sub.4 is a group represented by -(L.sub.1)-(R.sub.1), a vinyl group, or an allyl group, Li is a substituted or unsubstituted C.sub.2-C.sub.20 alkenylene group or a substituted or unsubstituted C.sub.2-C.sub.20 alkynylene group, and Ri is hydrogen or a substituted or unsubstituted C.sub.2-C.sub.20 alkyl group.