The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Disclosed herein are compositions and methods for modulating the liver receptor homolog-1.

Substituted aryl- and heteroarylcarbonyl hydrazides

The invention relates to substituted aryl- and heteroarylcarbonyl hydrazides of the general formula (I) or salts thereof

##STR00001##

where the radicals of the formula (I) are each as defined in the description for enhancing stress tolerance in plants to abiotic stress, and for enhancing plant growth and/or for increasing plant yield.

An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. ##STR00001##
[in the above formula, R.sup.1 is, for example, a C.sub.1C.sub.6 alkyl group which is mono- or poly-substituted with halogen atom; R.sup.2 is, for example, a halogen atom or a C.sub.1C.sub.6 alkyl group; R.sup.3 is, for example, a hydrogen atom or a halogen atom; and R.sup.4 is, for example, a hydrogen atom or a C.sub.1C.sub.12 alkyl group.] The derivative or the salt has an excellent pest control effect.

An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. ##STR00001##
[in the above formula, R.sup.1 is, for example, a C.sub.1C.sub.6 alkyl group which is mono- or poly-substituted with halogen atom; R.sup.2 is, for example, a halogen atom or a C.sub.1C.sub.6 alkyl group; R.sup.3 is, for example, a hydrogen atom or a halogen atom; and R.sup.4 is, for example, a hydrogen atom or a C.sub.1C.sub.12 alkyl group.] The derivative or the salt has an excellent pest control effect.

The present invention provides sulfoxide compounds comprising hydrophobic ester or amide moieties such that the compounds have surfactant properties. Also provided are methods for using the sulfoxide compounds or mixtures of the sulfoxide compounds in a variety of applications.

The present invention provides sulfoxide compounds comprising hydrophobic ester or amide moieties such that the compounds have surfactant properties. Also provided are methods for using the sulfoxide compounds or mixtures of the sulfoxide compounds in a variety of applications.

Described herein are methods of oxidative coupling of aryl boron reagents with sp.sup.3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

Described herein are methods of oxidative coupling of aryl boron reagents with sp.sup.3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.