Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

The present invention relates to a process for the preparation of elafibranor and novel synthesis intermediates.

The present invention relates to a process for the preparation of elafibranor and novel synthesis intermediates.

The present invention relates to a process for the preparation of elafibranor and novel synthesis intermediates.

A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the alcohol or ester, the organic solvent further contains a catalyst having an alcohol dehydrogenation activity.

A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the alcohol or ester, the organic solvent further contains a catalyst having an alcohol dehydrogenation activity.

The present disclosure provides processes for preparing an alpha-hydroxy ester from the corresponding alpha-hydroxy acid by transesterification. Also provided are alphahydroxy esters prepared according to processes disclosed herein and compositions comprising the alpha-hydroxy esters.

The present disclosure provides processes for preparing an alpha-hydroxy ester from the corresponding alpha-hydroxy acid by transesterification. Also provided are alphahydroxy esters prepared according to processes disclosed herein and compositions comprising the alpha-hydroxy esters.

The present disclosure provides processes for preparing an alpha-hydroxy ester from the corresponding alpha-hydroxy acid by transesterification. Also provided are alphahydroxy esters prepared according to processes disclosed herein and compositions comprising the alpha-hydroxy esters.