The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

An aqueous composition including (a) metal ions including tin ions and silver ions and (b) at least one complexing agent of formula C11

R.sup.C12-X.sup.C11-R.sup.C11 (C11)

and their salts, where X.sup.C11 is selected from (a) a divalent 5 or 6 membered aromatic N-heterocyclic group; (b) a divalent 6 membered aromatic carbocyclic group; and (c) a divalent 5 or 6 membered aliphatic N-heterocyclic group including one N atom and optionally a second heteroatom selected from N and O; all of which may be unsubstituted or substituted by one or more OH or one or more R.sup.C14; R.sup.C11 is selected from

##STR00001## ; and R.sup.C12 is selected from R.sup.C11, X.sup.C11-R.sup.C11, H, OH, NR.sup.C14.sub.2, C.sub.1 to C.sub.10 alkyl, and C.sub.1 to C.sub.10 alkoxy

An aqueous composition including (a) metal ions including tin ions and silver ions and (b) at least one complexing agent of formula C11

R.sup.C12-X.sup.C11-R.sup.C11 (C11)

and their salts, where X.sup.C11 is selected from (a) a divalent 5 or 6 membered aromatic N-heterocyclic group; (b) a divalent 6 membered aromatic carbocyclic group; and (c) a divalent 5 or 6 membered aliphatic N-heterocyclic group including one N atom and optionally a second heteroatom selected from N and O; all of which may be unsubstituted or substituted by one or more OH or one or more R.sup.C14; R.sup.C11 is selected from

##STR00001## ; and R.sup.C12 is selected from R.sup.C11, X.sup.C11-R.sup.C11, H, OH, NR.sup.C14.sub.2, C.sub.1 to C.sub.10 alkyl, and C.sub.1 to C.sub.10 alkoxy

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.

Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.

Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.

Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.