The present disclosure discloses a water-soluble ynamide coupling reagent and a method for using the water-soluble ynamide coupling reagent in the synthesis of amide, polypeptide, ester and thioester compound. The ynamide coupling reagent has the structure represented by the following formula (I): ##STR00001##
and in the formula (I), R is one selected from the group consisting of methylsulfonyl, benzenesulfonyl, p-toluenesulfonyl, trifluoroacetyl and other electron withdrawing groups.

Alkylsulfenyl thiocarbonates capable of releasing hydropersulfides (RSSH) and carbonyl sulfide (COS) under physiological conditions and their use for treating or preventing disorders, diseases, or conditions associated with oxidative stress, impaired FeS cluster biosynthesis, including Friedreich's Ataxia, and anthracycline-induced cardiotoxicity, including cardiomyopathy and heart failure, are described.

Alkylsulfenyl thiocarbonates capable of releasing hydropersulfides (RSSH) and carbonyl sulfide (COS) under physiological conditions and their use for treating or preventing disorders, diseases, or conditions associated with oxidative stress, impaired FeS cluster biosynthesis, including Friedreich's Ataxia, and anthracycline-induced cardiotoxicity, including cardiomyopathy and heart failure, are described.