The invention belongs to the field of mineral flotation collector materials, and particularly discloses a method for preparing thionocarbamate. In the preparation process, xanthate and 2-haloethanol are esterified to obtain O-alkyl-S-hydroxyethyl xanthate, and then O-alkyl-S-hydroxyethyl xanthate and fatty amine are reacted to obtain a mixture of thionocarbamate and 2-mercaptoethanol. The mixture of thionocarbamate and 2-mercaptoethanol is washed with alkali, and the oil phase and water phase are separated. The oil phase and water phase are thionocarbamate and 2-hydroxyethylthiolate, respectively, and 2-mercaptoethanol is obtained by washing with an acid. 2-alkylthioethanol is obtained by reacting 2-hydroxyethanethiolate with alkyl halide, and then with carbon disulfide and alkali to prepare O-alkylthioethyl xanthate. Thionocarbamate, 2-mercaptoethanol and O-alkylthioethyl xanthate prepared by this method possess high yield and high purity. The process is green and environmentally friendly, and is beneficial to the industrialization of co-production.

The invention belongs to the field of mineral flotation collector materials, and particularly discloses a method for preparing thionocarbamate. In the preparation process, xanthate and 2-haloethanol are esterified to obtain O-alkyl-S-hydroxyethyl xanthate, and then O-alkyl-S-hydroxyethyl xanthate and fatty amine are reacted to obtain a mixture of thionocarbamate and 2-mercaptoethanol. The mixture of thionocarbamate and 2-mercaptoethanol is washed with alkali, and the oil phase and water phase are separated. The oil phase and water phase are thionocarbamate and 2-hydroxyethylthiolate, respectively, and 2-mercaptoethanol is obtained by washing with an acid. 2-alkylthioethanol is obtained by reacting 2-hydroxyethanethiolate with alkyl halide, and then with carbon disulfide and alkali to prepare O-alkylthioethyl xanthate. Thionocarbamate, 2-mercaptoethanol and O-alkylthioethyl xanthate prepared by this method possess high yield and high purity. The process is green and environmentally friendly, and is beneficial to the industrialization of co-production.

The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's extend the buffering range resulting in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's extend the buffering range resulting in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

What is described is a compound of formula I ##STR00001##
consisting of a compound in which R.sub.1 is a branched chain alkyl consisting of 10 to 31 carbons; R.sub.2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L.sub.1 and L.sub.2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X.sub.1 is S or O; R.sub.3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R.sub.4 and R.sub.5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

What is described is a compound of formula I ##STR00001##
consisting of a compound in which R.sub.1 is a branched chain alkyl consisting of 10 to 31 carbons; R.sub.2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L.sub.1 and L.sub.2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X.sub.1 is S or O; R.sub.3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R.sub.4 and R.sub.5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.