The present invention provides a compound represented by formula (I) [wherein L represents an oxygen atom or CH.sub.2, E represents a C2-C10 chain hydrocarbon group or the like, R.sup.1 represents a C1-C3 chain hydrocarbon group or the like, R.sup.2 represents a C1-C3 chain hydrocarbon group or the like, and n is 0, 1, 2 or 3.] or its N oxide or agriculturally acceptable salt, which is a compound that have excellent pests controlling effects. ##STR00001##

The present invention provides a compound represented by formula (I) [wherein L represents an oxygen atom or CH.sub.2, E represents a C2-C10 chain hydrocarbon group or the like, R.sup.1 represents a C1-C3 chain hydrocarbon group or the like, R.sup.2 represents a C1-C3 chain hydrocarbon group or the like, and n is 0, 1, 2 or 3.] or its N oxide or agriculturally acceptable salt, which is a compound that have excellent pests controlling effects. ##STR00001##

The present invention relates to the new chemical compounds containing (Z)-1,2-diphenylethene moiety in the structures, particularly the new derivatives of cis-stilbene, the new derivatives of 4,5-diphenyl-1,3-oxazole, the new derivatives of 1-methyl-4,5-diphenyl-1H-imidazole and pharmaceutically acceptable salts thereof. The invention relates also to the application of aforementioned compounds as a microtubule-interfering agents (MIAs). The new derivatives, because of their potential antimitotic and antiangio-genic activity, can be used as ingredients in the preparations used in the treatment of cancer.

The present invention relates to the new chemical compounds containing (Z)-1,2-diphenylethene moiety in the structures, particularly the new derivatives of cis-stilbene, the new derivatives of 4,5-diphenyl-1,3-oxazole, the new derivatives of 1-methyl-4,5-diphenyl-1H-imidazole and pharmaceutically acceptable salts thereof. The invention relates also to the application of aforementioned compounds as a microtubule-interfering agents (MIAs). The new derivatives, because of their potential antimitotic and antiangio-genic activity, can be used as ingredients in the preparations used in the treatment of cancer.

What is described is a method of synthesis of the compound of formula 1A,

##STR00001##

or a salt thereof, wherein R.sub.3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R.sub.4 and R.sub.5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L.sub.3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.

Here described is a method of delivery of a drug to a stellate cell using a composition comprising a compound of formula I:

##STR00001##

wherein R.sub.1 and R.sub.2 are independently selected from C.sub.10 to C.sub.18 alkyl, C.sub.12 to C.sub.18 alkenyl, and oleoyl; R.sub.3 and R.sub.4 are independently selected from C.sub.1 to C.sub.6 alkyl and C.sub.2 to C.sub.6 alkanol; X is selected from CH.sub.2, S, and O, or X is absent; Y is selected from (CH.sub.2).sub.n, S(CH.sub.2).sub.n, O(CH.sub.2).sub.n, -thiophene-, -SO.sub.2(CH.sub.2).sub.n, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z.sup. is a counterion.

Here described is a method of delivery of a drug to a stellate cell using a composition comprising a compound of formula I:

##STR00001##

wherein R.sub.1 and R.sub.2 are independently selected from C.sub.10 to C.sub.18 alkyl, C.sub.12 to C.sub.18 alkenyl, and oleoyl; R.sub.3 and R.sub.4 are independently selected from C.sub.1 to C.sub.6 alkyl and C.sub.2 to C.sub.6 alkanol; X is selected from CH.sub.2, S, and O, or X is absent; Y is selected from (CH.sub.2).sub.n, S(CH.sub.2).sub.n, O(CH.sub.2).sub.n, -thiophene-, -SO.sub.2(CH.sub.2).sub.n, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z.sup. is a counterion.

Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of formula (I) ##STR00001##
In which X and Y are selected from, R.sup.1, and OR.sup.1 and NR.sub.2, B is oxygen or sulphur S is sulphur, R.sup.1 is selected from C.sub.1-C.sub.15 hydrocarbon groups, optionally contain a heteroatom selected from halogen, P, S, N, O and Si, which can be fused together to form one or more cycles, R is hydrogen or R.sup.1 and A is a bivalent bridging group with chain length between the two bridging bonds being 1-10 atoms.

Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of formula (I) ##STR00001##
In which X and Y are selected from, R.sup.1, and OR.sup.1 and NR.sub.2, B is oxygen or sulphur S is sulphur, R.sup.1 is selected from C.sub.1-C.sub.15 hydrocarbon groups, optionally contain a heteroatom selected from halogen, P, S, N, O and Si, which can be fused together to form one or more cycles, R is hydrogen or R.sup.1 and A is a bivalent bridging group with chain length between the two bridging bonds being 1-10 atoms.

What is described is a compound of formula I

##STR00001##

wherein R.sub.1 is a linear alkyl, alkenyl, or alkynyl of 2 to 12 carbons, or a branched alkyl with 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, or 7 carbons, R.sub.2 is a branched alkyl with 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, or 7 carbons, L.sub.1 and L.sub.2 are independently a linear alkylene with 1-18 carbons or alkenylene with 2-18 carbons, X is S or O, L.sub.3 is a bond or an alkylene with 1 to 6 carbons, R.sub.3 is an alkylene with 1 to 6 carbons, and R.sub.4 and R.sub.5 are the same or different, each a linear or branched alkyl with 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.