Described herein are ortho-dimethyl-substituted and tetramethyi-substituted triptycene-containing diamine monomers and microporous triptycene-based poiyimides and poiyamides, and methods of making the monomers and polymers.

Biguanide compounds of formula

##STR00001##

where R.sup.1 comprises a cubanyl-substituted alkyl and R.sup.2 comprises a substituted or unsubstituted alkyl, and their use in the treatment of cancers and viral infections are described.

The present invention relates to a novel spirofluorene compound and an organic light-emitting device including same. The spirofluorene compound according to the present invention is a polycyclic compound to which at least one amino substituent is introduced and which has a structure in which indene, indole, benzofuran, benzothiophene, or benzosilole is fused to a 9,9-spirobifluorene moiety.

Provided is a compound of Formula (I):

##STR00001## wherein the variable groups are defined herein.

There are described ROR modulators of the formula (I), ##STR00001##
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR activity, for example, autoimmune and/or inflammatory disorders.

A production method for producing a target compound represented by the following formula (1), the production method including: a step (A) of subjecting a mixed liquid containing a starting compound represented by the following formula (2) and a solvent to a hydrogenation reduction in the presence of a catalyst having hydrogenation ability, wherein, in the step (A), water is removed from the reaction system:

##STR00001##

wherein R represents H, CH.sub.3, or C.sub.2H.sub.5,

##STR00002##

wherein R represents H, CH.sub.3, or C.sub.2H.sub.5, and R.sub.1 represents CH.sub.3, C.sub.2H.sub.5, C.sub.3H.sub.7, or C.sub.4H.sub.9.

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

This invention relates to the direct grafting of a calixarene mostly onto the surface of a material, as well as to a grafting process, and certain calixarene intermediates useful for carrying the grafting process.

Embodiments of the present disclosure provide for an ortho (o)-hydroxy-functionalized diamine, a method of making an o-hydroxy-functionalized diamine, an o-hydroxy-functionalized diamine-based polyimide, a method of making an o-hydroxy-functionalized diamine imide, methods of gas separation, and the like.