Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect. The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. ##STR00001##

Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect. The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. ##STR00001##

Inhibitors of MDM2 and MDM2-related proteins and compositions containing the same are disclosed. Methods of using the MDM2 inhibitors in the treatment of diseases and conditions wherein inhibition of an interaction between p53 and MDM2 provides a benefit, like cancers, also are disclosed.

The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to new anticancer miliusane lactam compounds. The present invention also includes its preparation and application method for treating cancer.

The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to new anticancer miliusane lactam compounds. The present invention also includes its preparation and application method for treating cancer.

The present invention relates to novel effective alkynyl-substituted N-phenylpyrrolidine-2,4-diones according to the general formula (I) or agrochemically acceptable salts thereof,

##STR00001##

where
X=C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-haloalkyl or C.sub.3-C.sub.6-cycloalkyl, Y=C.sub.1-C.sub.4-alkyl or C.sub.3-C.sub.6-cycloalkyl, R.sup.1=hydrogen, C.sub.1-C.sub.6-alkyl, or C.sub.3-C.sub.6-cycloalkyl, R.sup.2=hydrogen or methyl, R.sup.3=C.sub.1-C.sub.6-alkyl or C.sub.1-C.sub.6-alkoxy-C.sub.2-C.sub.6-alkyl, G=hydrogen, a cleavable group L or a cation E.

The invention further relates to a herbicidal composition comprising a compound of the general formula (I) and to the use of the compounds according to the invention for controlling weeds and weed grasses in crops of useful plants.

The present invention relates to novel effective alkynyl-substituted N-phenylpyrrolidine-2,4-diones according to the general formula (I) or agrochemically acceptable salts thereof,

##STR00001##

where
X=C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-haloalkyl or C.sub.3-C.sub.6-cycloalkyl, Y=C.sub.1-C.sub.4-alkyl or C.sub.3-C.sub.6-cycloalkyl, R.sup.1=hydrogen, C.sub.1-C.sub.6-alkyl, or C.sub.3-C.sub.6-cycloalkyl, R.sup.2=hydrogen or methyl, R.sup.3=C.sub.1-C.sub.6-alkyl or C.sub.1-C.sub.6-alkoxy-C.sub.2-C.sub.6-alkyl, G=hydrogen, a cleavable group L or a cation E.

The invention further relates to a herbicidal composition comprising a compound of the general formula (I) and to the use of the compounds according to the invention for controlling weeds and weed grasses in crops of useful plants.

The present invention relates to novel herbicidally active 3-phenylpyrrolin-2-ones of the general formula (I) or agrochemically acceptable salts thereof and to their use for controlling broad-leaved weeds and weed grasses in crops of useful plants.