The present invention relates to novel herbicidally active 3-phenylpyrrolidine-2,4-diones of the general formula (I) or agrochemically acceptable salts thereof and to their use for controlling broad-leaved weeds and weed grasses in crops of useful plants.

There is herein provided a compound of formula I or a pharmaceutically acceptable salt thereof, wherein X, R.sup.1, R.sup.2, R.sup.3, ring A, n and y have meanings as provided in the description.

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There is herein provided a compound of formula I or a pharmaceutically acceptable salt thereof, wherein X, R.sup.1, R.sup.2, R.sup.3, ring A, n and y have meanings as provided in the description.

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The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.

The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.

The invention of the instant application discloses spirocyclic guanidine compounds of general formula (I), shown below, and their use in methods of treating cancer

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Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.

The present invention relates to alkynyl-substituted N-phenylpyrrolidine-2,4-diones according to the general formula (I) or agrochemically acceptable salts thereof, ##STR00001##
where X=C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-haloalkyl or C.sub.3-C.sub.6-cycloalkyl, Y=C.sub.1-C.sub.4-alkyl or C.sub.3-C.sub.6-cycloalkyl, R.sup.1=hydrogen, C.sub.1-C.sub.6-alkyl, or C.sub.3-C.sub.6-cycloalkyl, R.sup.2=hydrogen or methyl, R.sup.3=C.sub.1-C.sub.6-alkyl or C.sub.1-C.sub.6-alkoxy-C.sub.2-C.sub.6-alkyl, G=hydrogen, a cleavable group L or a cation E. The invention further relates to a herbicidal composition comprising a compound of the general formula (I) and to the use of the compounds according to the invention for controlling weeds and weed grasses in crops of useful plants.

The present invention relates to alkynyl-substituted N-phenylpyrrolidine-2,4-diones according to the general formula (I) or agrochemically acceptable salts thereof, ##STR00001##
where X=C.sub.1-C.sub.4-alkyl, C.sub.1-C.sub.4-haloalkyl or C.sub.3-C.sub.6-cycloalkyl, Y=C.sub.1-C.sub.4-alkyl or C.sub.3-C.sub.6-cycloalkyl, R.sup.1=hydrogen, C.sub.1-C.sub.6-alkyl, or C.sub.3-C.sub.6-cycloalkyl, R.sup.2=hydrogen or methyl, R.sup.3=C.sub.1-C.sub.6-alkyl or C.sub.1-C.sub.6-alkoxy-C.sub.2-C.sub.6-alkyl, G=hydrogen, a cleavable group L or a cation E. The invention further relates to a herbicidal composition comprising a compound of the general formula (I) and to the use of the compounds according to the invention for controlling weeds and weed grasses in crops of useful plants.

The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.

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