The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.

Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.

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In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

Radioprotector compounds including 3,3-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.

Radioprotector compounds including 3,3-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.

Novel tetraphenylene anthracene compounds are disclosed, which can be used as charge transporting materials, emitters, hosts in an organic electroluminescent device. These novel compounds offer better device performance. Also disclosed are an electroluminescent device and a formulation.

A tandem organic light-emitting diode, an array substrate and a display device are provided. The tandem organic light-emitting diode includes an anode, a hole transport layer, a first light-emitting layer, a first charge generation layer, a second charge generation layer, a third charge generation layer, a fourth charge generation layer, a second light-emitting layer, an electron transport layer and a cathode which are sequentially laminated, wherein the first charge generation layer is an N-type bulk heterojunction, the second charge generation layer and the third charge generation layer are both PN junction type bulk heterojunctions, a proportion of the P-type organic material in the second charge generation layer is greater than that of the N-type organic material, a proportion of the P-type organic material in the third charge generation layer is less than that of the N-type organic material, and the fourth charge generation layer is a P-type bulk heterojunction.

A tandem organic light-emitting diode, an array substrate and a display device are provided. The tandem organic light-emitting diode includes an anode, a hole transport layer, a first light-emitting layer, a first charge generation layer, a second charge generation layer, a third charge generation layer, a fourth charge generation layer, a second light-emitting layer, an electron transport layer and a cathode which are sequentially laminated, wherein the first charge generation layer is an N-type bulk heterojunction, the second charge generation layer and the third charge generation layer are both PN junction type bulk heterojunctions, a proportion of the P-type organic material in the second charge generation layer is greater than that of the N-type organic material, a proportion of the P-type organic material in the third charge generation layer is less than that of the N-type organic material, and the fourth charge generation layer is a P-type bulk heterojunction.