The invention relates to a method for preparing a compound (I) or one of the salts thereof, and the uses of said method, R.sup.1OOCC(X)CHR.sup.2R.sup.3(I), wherein X is selected among O; NR, wherein R is H or a C1-C6 alkyl; and NOR wherein R is H, or a C1-C6 alkyl or an alkylaryl; R.sup.1 is H or a C1-C6 alkyl group; R.sup.2 is H, a C1-C6 alkyl, or an alkylaryl; and R.sup.3 is CH.sub.2SR.sup.4 or CH.sub.2SeR.sup.4, where R.sup.4 is H or a C1-C6 alkyl from a compound (II), or one of the salts thereof, R.sup.1OOCC(X)CHR.sup.2R.sup.5 and R.sup.5 is H or COOR.sup.6, where R.sup.6 is H or a C1-C6 alkyl, said method being carried out in the presence of a compound (III) CH.sub.2(Y)(Z). Wherein Y is H; OR.sup.7, where R.sup.7 is H, a C1-C6 alkyl or an acyl with formula COR.sup.4; SR.sup.4 or SeR.sup.4 where R.sup.4 matches the preceding definition; or 1 NR.sup.8R.sup.9, where R.sup.8 and R.sup.9, identical or different, each or together are a C1-C6 alkyl, or an alkylaryl; Z, identical or different to Y, is OR.sup.10 where R.sup.10 is H, a C1-C6 alkyl or COR.sup.4; a cyclic or acyclic N(COR.sup.4)(COR.sup.4) group; or NR.sup.11R.sup.12, where R.sup.11 and R.sup.12, identical or different, each or together are a C1-C6 alkyl or an alkylaryl; wherein Y and Z together are O; said method involving an intermediate product (IV) R.sup.1OOCC(X)CHR.sup.2CH.sub.2Z.

The invention relates to a method for preparing a compound (I) or one of the salts thereof, and the uses of said method, R.sup.1OOCC(X)CHR.sup.2R.sup.3(I), wherein X is selected among O; NR, wherein R is H or a C1-C6 alkyl; and NOR wherein R is H, or a C1-C6 alkyl or an alkylaryl; R.sup.1 is H or a C1-C6 alkyl group; R.sup.2 is H, a C1-C6 alkyl, or an alkylaryl; and R.sup.3 is CH.sub.2SR.sup.4 or CH.sub.2SeR.sup.4, where R.sup.4 is H or a C1-C6 alkyl from a compound (II), or one of the salts thereof, R.sup.1OOCC(X)CHR.sup.2R.sup.5 and R.sup.5 is H or COOR.sup.6, where R.sup.6 is H or a C1-C6 alkyl, said method being carried out in the presence of a compound (III) CH.sub.2(Y)(Z). Wherein Y is H; OR.sup.7, where R.sup.7 is H, a C1-C6 alkyl or an acyl with formula COR.sup.4; SR.sup.4 or SeR.sup.4 where R.sup.4 matches the preceding definition; or 1 NR.sup.8R.sup.9, where R.sup.8 and R.sup.9, identical or different, each or together are a C1-C6 alkyl, or an alkylaryl; Z, identical or different to Y, is OR.sup.10 where R.sup.10 is H, a C1-C6 alkyl or COR.sup.4; a cyclic or acyclic N(COR.sup.4)(COR.sup.4) group; or NR.sup.11R.sup.12, where R.sup.11 and R.sup.12, identical or different, each or together are a C1-C6 alkyl or an alkylaryl; wherein Y and Z together are O; said method involving an intermediate product (IV) R.sup.1OOCC(X)CHR.sup.2CH.sub.2Z.

The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, having same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.

The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, having same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.

This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula I, where n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; and R.sub.1-R.sub.6 are as defined herein.

##STR00001##

This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula I, where n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; and R.sub.1-R.sub.6 are as defined herein.

##STR00001##

The invention provides compounds, compositions, methods and kits for the treatment of pain, itch, and neurogenic inflammation.

The invention provides compounds, compositions, methods and kits for the treatment of pain, itch, and neurogenic inflammation.

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

##STR00001##

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

##STR00001##