Patent classifications
C07D211/94
Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith
- Massimo Ammirante ,
- Sogole Bahmanyar ,
- Matthew D. Correa ,
- Virginia Grant ,
- Joshua Hansen ,
- Evan J. Horn ,
- Timothy S. Kercher ,
- Christopher Mayne ,
- Mark A. Nagy ,
- Rama Krishna Narla ,
- Surendra Nayak ,
- Stephen Norris ,
- Patrick Papa ,
- Veronique Plantevin-Krenitsky ,
- John J. Sapienza ,
- Brandon W. Whitefield ,
- Shuichan Xu
Provided herein are piperidine dione compounds having the following structure: ##STR00001## wherein R.sup.N, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith
- Massimo Ammirante ,
- Sogole Bahmanyar ,
- Matthew D. Correa ,
- Virginia Grant ,
- Joshua Hansen ,
- Evan J. Horn ,
- Timothy S. Kercher ,
- Christopher Mayne ,
- Mark A. Nagy ,
- Rama Krishna Narla ,
- Surendra Nayak ,
- Stephen Norris ,
- Patrick Papa ,
- Veronique Plantevin-Krenitsky ,
- John J. Sapienza ,
- Brandon W. Whitefield ,
- Shuichan Xu
Provided herein are piperidine dione compounds having the following structure: ##STR00001## wherein R.sup.N, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES
Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides:
##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, Q.sup.1, Q.sup.2, J, Y.sup.1, and Y.sup.2 are as defined in the disclosure.
Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound, N-oxide, salt or composition.
SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES
Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides:
##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, Q.sup.1, Q.sup.2, J, Y.sup.1, and Y.sup.2 are as defined in the disclosure.
Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound, N-oxide, salt or composition.
POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS
The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerisable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment (PS, PSA) and self-aligning (SA) type.
POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS
The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerisable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment (PS, PSA) and self-aligning (SA) type.
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
FLUORINE-CONTAINING COMPOUND AND CONTRAST AGENT
The fluorine-containing compound includes: two nitroxide radical-containing groups represented by Formula (1) (R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are each independently a C1-10 alkyl group unsubstituted or substituted with a substituent containing no fluorine atoms); and one to three —O—C(CF.sub.3).sub.3 groups, in which the nitroxide radical-containing groups are bound to the —O—C(CF.sub.3).sub.3 groups through a chain structure with 2 to 17 atoms.
##STR00001##
Anti-foulant formulation for compressors
Disclosed are compositions and methods for preventing or reducing polymer formation and polymer deposition in equipment used in petrochemical processes. An antifoulant composition includes a combination of one or more antioxidants; one or more antipolymerants; one or more dispersants; and one or more solvents. A method of preventing or reducing fouling of process equipment used in an industrial process is also described. The method includes introducing into the process equipment an antifoulant composition, the antifoulant composition comprising a combination of one or more antioxidants; one or more antipolymerants; one or more dispersants; and one or more solvents.